ID A0A3Q0DDA2_MESAU Unreviewed; 307 AA.
AC A0A3Q0DDA2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=protein acetyllysine N-acetyltransferase {ECO:0000256|ARBA:ARBA00012928};
DE EC=2.3.1.286 {ECO:0000256|ARBA:ARBA00012928};
GN Name=Sirt6 {ECO:0000313|RefSeq:XP_021090504.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021090504.1};
RN [1] {ECO:0000313|RefSeq:XP_021090504.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sirtuin family. Class IV subfamily.
CC {ECO:0000256|ARBA:ARBA00038170}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00236}.
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DR RefSeq; XP_021090504.1; XM_021234845.1.
DR AlphaFoldDB; A0A3Q0DDA2; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR003000; Sirtuin.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR11085:SF13; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6; 1.
DR Pfam; PF02146; SIR2; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 27..245
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
FT REGION 262..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33433 MW; B8C0B786D1FC99E8 CRC64;
MSVNYAAGLS PYADKGKCGL PEVFDPPEEL ERKVRELARL VRQSPRVVFH TGAGISTACG
IPDFRGPHGV WTMEERGLAP KFDTTFESAR PSKTHMALVQ LERAGFLSFL VSQNVDGLHV
RSGFPRDKLA ELHGNMFVEE CPKCKMQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRTA
DLSVTLGTSL QIRPSGNLPL ATKRRGGRLV IVNLQPTKHD RQADLRIHGY VDEVMSGLMK
HLGLEIPAWD GPCVLDKALP PLPRPAAPKT EPPAHLNGSV HAACKPEPNS SVPHRPPKRV
KTEAAPS
//
