ID A0A3Q0DF85_MESAU Unreviewed; 583 AA.
AC A0A3Q0DF85;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase {ECO:0000256|ARBA:ARBA00026102};
DE EC=3.6.1.62 {ECO:0000256|ARBA:ARBA00026102};
GN Name=Dcp1a {ECO:0000313|RefSeq:XP_021091677.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021091677.1};
RN [1] {ECO:0000313|RefSeq:XP_021091677.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_021091677.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [3] {ECO:0000313|RefSeq:XP_021091677.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
CC in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) +
CC N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692,
CC Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461;
CC EC=3.6.1.62; Evidence={ECO:0000256|ARBA:ARBA00024496};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485;
CC Evidence={ECO:0000256|ARBA:ARBA00024496};
CC -!- SIMILARITY: Belongs to the DCP1 family.
CC {ECO:0000256|ARBA:ARBA00008778}.
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DR RefSeq; XP_021091677.1; XM_021236018.1.
DR AlphaFoldDB; A0A3Q0DF85; -.
DR STRING; 10036.ENSMAUP00000003872; -.
DR OrthoDB; 385293at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd09804; Dcp1; 1.
DR Gene3D; 6.10.140.2030; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010334; Dcp1.
DR InterPro; IPR031953; mRNA_decap_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16290:SF4; MRNA-DECAPPING ENZYME 1A; 1.
DR PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR Pfam; PF06058; DCP1; 1.
DR Pfam; PF16741; mRNA_decap_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 3: Inferred from homology;
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 542..581
FT /note="mRNA-decapping enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16741"
FT REGION 171..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 63044 MW; 4790772E699E463B CRC64;
MESLSRAGQE MSLAALKQHD PYITSIADLT GQVALYTFCP KANQWEKTDI EGTLFVYRRS
ASPYHGFTIV NRLNMHNLVE PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK
LMADVVEEET RRCQQAAREK QSPSQANGCS DQRPIDILEM LSRAKDEYEK NQMGGSNISS
PGLQPSTQLS NLGSTETLEE TPSGLQDKSA PSGHKHLTVE ELFGTSLPKE QPAAVGLESE
DVEKLPGDAS QKEPGSFLPL PFEQSGGTPQ SDSLGVRSVA HHTVVQPEVA TPVLITPASI
AQSAEKHAPN YTIPLSPVLS PTLPAEAPVT QVPHLPRNST MMQAVKTTPR QKSPLLNQPV
PELSHSSLIA SQSPFRAPVS LSSTTGTSLP SADLLQKLRL TSQHDQIQAQ PLGKGAMAPN
FSSAAGQLAT PESFIEPPSK TAAARAANSA SLSNMVLAPT LQSMQQNQDP EVFAQPKVLP
GAVPIAGPAL ATAATAAVSS ILLSPSVFQQ TVPRSTDLER KASSPSPLTV GTPENQRRPS
IILSKSQLQD TLIHLIKNDS SFLSTLHEVY LQVLTKNKDK HNL
//
