ID   A0A3Q0DFB1_MESAU        Unreviewed;      1099 AA.
AC   A0A3Q0DFB1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=NACHT, LRR and PYD domains-containing protein 2 isoform X2 {ECO:0000313|RefSeq:XP_021091697.1};
GN   Name=Nlrp2 {ECO:0000313|RefSeq:XP_021091697.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021091697.1};
RN   [1] {ECO:0000313|RefSeq:XP_021091697.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   RefSeq; XP_021091697.1; XM_021236038.1.
DR   AlphaFoldDB; A0A3Q0DFB1; -.
DR   STRING; 10036.ENSMAUP00000016758; -.
DR   KEGG; maua:101830027; -.
DR   Proteomes; UP000189706; Unplaced.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF14; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 8.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT   DOMAIN          165..296
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          359..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1074..1099
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..413
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1084..1099
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1099 AA;  125267 MW;  CA606E2805FFFFB4 CRC64;
     MRNPRKQQFT MKDILKTLTQ AELSNFKSVL KNWFLPHTLK QIPQIALNMA DADHVVEILH
     EYCPSDWIEI IIKEVLQTIN QLDKAELVRK QLEGNTISSP GSMKPTAFGA ESPEHKHKKK
     WKKEYRVRWK FNFWPKCIEN FYVETESYRT LLTLCNPKAK MPSAHAIVLH GPPNSGKTTM
     AMRLMLQWSE SKQAQMFPCA FFISCRAVNN TKSCTFAQLL SLKSASRRDY VEKSLALEEK
     LLFVVDGFDE LRVPAGALFQ DICSDWNTKK PAAVLLSSLL KRKMAPHATL LVTTQTQTLR
     QIYLMIDQPF LIENQGFSEQ DIQEYFQRFF NDEVGKEKKG EVSLFGEFGE FGEFGEFGKV
     VEEKGGDDDD EEGEEEEEEE GEEEEEEEEE GEEEEEEGEE EDSEEEEEEE EEEKAMRALN
     AVRCNAALYD MASSPAASLI FCLCLEIAMK KGEDLALICQ SQTSMFLNFL CKMFSPETYE
     SYLKNIFQIS FKNLCLLAVN NLLEQLPILS KKDLLELLLD REILHPFLCR YIVKSDDYSY
     CYSFVYLKVQ QLLAAIAFAD GLENDTSKYI MQNMLSKEAR LKNPNLSGVL LFIFGLLNET
     RLQELATIFD WQISIGVKRK FLECEPGENK PFLLLMDLQE ILSCLYESQE EGFVKEAMAL
     FEEISLHLKT NMDLMHASFC LKNSQNLQTV SLQVEKGIFP ENDDVLESTA RDQGSQDDQR
     LLNFWTDFCD MFHSNKKLVF LDISESFLSS SSLQILCDKL SSSACHLQKV VLKNISPADA
     YKKLCLIFNG YETLSHLTLK GDNLCTILPS LCGVVKHPSC KLKYLSLSSC PTAIQKWNDF
     FQVLKVSQSL TCLDLTDNKL LDQGIRLLCN TWKQPNNTLQ RVSLENCHLT EGCCKDISSI
     LVVSQTLTHL NLAKNTLGDN GVKILCESLS YPECKLQTLV LWSCNITSDG CCHLSKMLRQ
     TPSLKHLDLG QNCIRNAGAK FLCEALKEPH SNLKSLWLCG CSMTPANCQD FSKILRNNKS
     LNTLDLAQNS LGTDAIKTFC EDLKLGICPL QTLRLKFDDA NPSIQKLIQK MKESHPQLTI
     NSDQPDPRKK EPSFPHFIF
//