ID A0A3Q0DFC8_MESAU Unreviewed; 495 AA.
AC A0A3Q0DFC8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=P2X purinoceptor {ECO:0000256|RuleBase:RU000681};
GN Name=P2rx2 {ECO:0000313|RefSeq:XP_021091717.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021091717.1};
RN [1] {ECO:0000313|RefSeq:XP_021091717.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel.
CC {ECO:0000256|RuleBase:RU000681}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000681}.
CC -!- SIMILARITY: Belongs to the P2X receptor family.
CC {ECO:0000256|ARBA:ARBA00009848, ECO:0000256|RuleBase:RU000681}.
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DR RefSeq; XP_021091717.1; XM_021236058.1.
DR AlphaFoldDB; A0A3Q0DFC8; -.
DR GlyCosmos; A0A3Q0DFC8; 1 site, No reported glycans.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004931; F:extracellularly ATP-gated monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0001614; F:purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0033198; P:response to ATP; IEA:InterPro.
DR Gene3D; 1.10.287.940; atp-gated p2x4 ion channel; 1.
DR Gene3D; 2.60.490.10; atp-gated p2x4 ion channel domain; 1.
DR InterPro; IPR003045; P2X2_purnocptor.
DR InterPro; IPR027309; P2X_extracellular_dom_sf.
DR InterPro; IPR001429; P2X_purnocptor.
DR NCBIfam; TIGR00863; P2X; 1.
DR PANTHER; PTHR10125; P2X PURINOCEPTOR; 1.
DR PANTHER; PTHR10125:SF4; P2X PURINOCEPTOR 2; 1.
DR Pfam; PF00864; P2X_receptor; 1.
DR PIRSF; PIRSF005713; P2X_purinoceptor; 1.
DR PRINTS; PR01309; P2X2RECEPTOR.
DR PRINTS; PR01307; P2XRECEPTOR.
DR PROSITE; PS01212; P2X_RECEPTOR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR005713-1};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR005713-2};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU000681};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000681}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR005713-1};
KW Receptor {ECO:0000256|RuleBase:RU000681};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000681}.
FT REGION 416..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 94..96
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT BINDING 209
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT BINDING 311..313
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT BINDING 331
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-3"
FT DISULFID 138..189
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 149..172
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 155..183
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 237..247
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
SQ SEQUENCE 495 AA; 54787 MW; 01A1A67364CFAB6F CRC64;
MAAAQPGLPA GAAMVQRLVR GCWSAFWDYE TPKVIVVRNR RLGFVHRTVQ LLILLYFVWV
ASRTGTALFL RYVFIVQKSY QDSETGPESS IITKVKGITI SEHKVWDVEE YVKPPEGGSV
VSIITRMEVT PSQTLGTCPE SMKVHSSACH SDDDCVAGQL DMQGNGIRTG HCVPYYHGDS
KTCEVSAWCP VEDGTSENQF LGKMAPNFTI LIKNNIHYPK FKFSKGNIAS QKNLKHCTFD
QDSDPYCPIF KLGFIVEQAG ENFTELAHKG GVIGVIINWN CDLDLSESEC NPKYSFRRLD
PKYDPASSGY NFRFAKYYKI NSTTTTRTLI KAYGIRIDVI VHGQAGKFSL IPTIINLATA
LTSIGVGSFL CDWILLTFMN KNKLYSHKKF DKVRTPRHTS NSWPVTLALV LGQIPPPPSH
YPQDQSPSPP SGRGSTLGEV AELPLAVQPP RPCSISALTE QVVDTLDLHV GQRLPVPEPS
QQDSTSTDPK GLAQL
//
