ID A0A3Q0DHK1_MESAU Unreviewed; 2696 AA.
AC A0A3Q0DHK1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Probable helicase senataxin {ECO:0000313|RefSeq:XP_021091799.1};
GN Name=Setx {ECO:0000313|RefSeq:XP_021091799.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021091799.1};
RN [1] {ECO:0000313|RefSeq:XP_021091799.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_021091799.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_021091799.1; XM_021236140.1.
DR STRING; 10036.ENSMAUP00000000537; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18042; DEXXQc_SETX; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|RefSeq:XP_021091799.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|RefSeq:XP_021091799.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_021091799.1};
KW Nucleotide-binding {ECO:0000313|RefSeq:XP_021091799.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 1901..2184
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 2192..2446
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 744..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2339..2360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2496..2517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2531..2560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2621..2696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2044..2103
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 744..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2541..2560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2639..2696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2696 AA; 303823 MW; C7A1B87BC959715D CRC64;
MSTCCWCTPG GASTVDVLKC YASSTGSSEF QTADEDLCYC LECVAEYHRA RDEVPFLHEV
LWELETSRLI NHFEKSMKAE VEDDELYIVD NNGEEQLFDC SGQDFENKLR VPLFEILKYP
YLLLHERVNE LCVEALCRME QTSCSFQVFD KYPGIYLFLV HPNEMIRRWA ILTARNLGKV
DRDDYYDLQE VLTCLFKVIE LGLLESPDIY TSSVLEKGKL ILLPAHMYDT TNYKNYWLGI
CMLLTILEEQ AMDSLLLGSD KQNDFMQSIL HTMERQSDDD SMNPFWPALH CFMVILDRLG
SKVWGQLIDP IEAFQTIINN VSYNREIQNI RNSSIRTKLE PEPHFDDMVT CSQIVYNYNP
EKTKKDSGWR SAICPDYCPN MYEEMETLAN VLQSDIGQDM RVHNSTFLWF IPFVQSLMDL
KDLGVAYIVE VIHHLYSEVK DVLNQTNAVC DKVTEFFILI LISVIELHRN KKCLHLLWVS
SQQWVDAVVK CAKLPTTAFA RSSEKSPGST PKGAAIISSL ALHSVPSNSV QLACVQLIRG
LLKEGYQLGQ QTLCKRFWDK LNLFLRGNLS LGWQLTAQET HELQMCLKQI IRNIKSKMPQ
YSTFGDLTSA CKTLPSFKEE SEQIDRKPKK DIYCLENYSP TYSKEPMKDD SNQVLINADN
TEEVGVKQHY IDLNLEEEEP LPAELCLKQE SEAFFSGNAQ EQVKISTEKS VKENSSCTPQ
NNTLRNVPEW GCDRGVIIST RSLTDSNTDS LGKVSTSNED VSLKDDTVGK NSKPKSKAQK
DEICARLSHV IKQQHRKSTL INNTINLEEN TAMSELENCS GKDRGVLKED AITHDVSSDS
VLDDEHTEQN SENSSLLKNK ELKSEESFNS DENKCQIQEH HATDDLLSFT EVTNTFVKKT
SCEGPVKVVE SRDKEMRKST VLTSNLVKGQ VPHGSSKPLV TGSQMDFCNK ALIAQSTVIQ
FPTGSSKNSS QLKRKDDRRC LTVNQNTADT CHGQVIVISD SDEDDDERSH GIEKYTKQGK
VCTGQECPEQ HGLVINTGVE RKLIKEEAKC PVEFEDSESQ VFEFESSSEV YSVWQDHNVD
IKNFFQEEGK SCVTHVADST INNLGCGADS VSEEVARNEA EDAEEHAEPH SVSAEEFCKI
EEKKRKRKRC DRVTAEDPQR PSSSVRPEQL ADDRDLAGID TRISASSSNV ERDSTVSPIK
STKPRTHSKP VRKVPASKAT KKTHSETKRG QTKSSCYISC RTSPAIVPPK KYRQCPEPTS
TVEKLGLKKA PRKAFELSQR SLECIVQLRD HGKTVGVVNA PKKTKLIAPQ TLSIKNKKLL
TSQDLQFQRL MRSRSHKKRD LDYKNTDISR TVPCTVQDSY VPVTDSDGPD NHRGSELPAN
SNEKQLAKCI PSKPEVAEAI SDPRVTDIAS LVNQCESRVL SGGVPTDVML LASEDPVGED
GPTLPVAEVA AVKAAEPESS SDTDDDNLFL TQHDPQDMDL CSQMENNKPI VVTHKDAIQR
EDSVSQPQLE SLSVTKCKYK DCVETTKNQS EFCPRHSEAK AADDDVFRKP GLPLSVARSL
RPTTTKIFSS SSASRTANLS KSLESTILQS ALKNKSSGVQ PNLKVTPPSS VVSKPVAEVK
SLCNIFNFQT PSSSNKQSYK LTLSDSKPVT ASSSVNIHLP SQSIFDTFIK EVLKWKYQMF
LNFDKCGAPT SLSQSISRPV PVRFQDCAEY FNVFLPLIIL NAFETVAQEW FNSPNKQNFY
HLHLRKFPAD YKKYWEFIIY LEESELAKQL HPKENDLVFL VPERLHRDKK DMSRNGMQDR
NGYYCGYVHK FRRTSVMRSG KAECSLCIQT QDNLPARLNE YTKCIVISSL VTTQRKLKAM
SLLSSRNQLA RAVLNPNPMD FCTKDLLTTS SERIITYLKD FNEDQKKAIE TAYAMVKQSP
SVAKICLIHG PPGTGKSKTI VGLLYRLLTE NQRKGHSNEN FNAKIKQNRV LVCAPSNAAV
DELMKKIILE FKEKCKDKKN PLGNCGDINL VRLGPEKSIN TEVLKFSLDS QVSHRMKKDL
PSHIQDMLRR KEFLDGQLDE ISRQRALCRG GREMQRQELD GCIVKIAKER QELASKIKEV
QGRPQKTQNT IILESHVICC TLSTSGGLLL ESAFRGQGGV PFSCVIVDEA GQSCEVETLS
PLIHRCNKLI LVGDPKQLPP TVISMKAQEY GYDQSMMARF CKLLEENVEQ NMIGRLPVLQ
LTIQYRMHPD ICLFPSNYVY NKNLKTNRMT EAIRCSSEWP FQPYLVFDVG DGSEQRDNDS
YINVQEIKLV MEIIKLIKDK KKDISSRNIG IITHYKAQKT MIQKDLEKEF DKKGLLQPIM
MGESRQQDPE ASNQRKKSSE CMHTSDELDC STFTQSGVSC VENGVTHTGP AEVDTVDAFQ
GRQKDCIIVT CVRASAVQGS IGFLASLQRL NVTITRAKYS LFILGHLRTL VENQHWYELI
QDAQKRGAII KTCDPNYRHD AMKILKLKPV LQRSLTHPPA TAPEVPRPQG GLPSNKLDSG
FAKTSFAASL CHTPSDTSDT VTSKEPERPP LQDRLRDPRL LRRLDAEAKG TFLKDAQPLN
PQLPGIVHRL LGESGIPLNF QDLSFIVPPS TAIVAPMNSN RSPLQAEIPP AHPAAPSTSK
RKYSDRDSGF SHRRESRASS EEERHGSVTH HMLRSADWDR RGLEHEDSSA KKRRFL
//
