ID   A0A3Q0DM72_CARSF        Unreviewed;       893 AA.
AC   A0A3Q0DM72;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Ankyrin repeat and LEM domain-containing protein 2 isoform X2 {ECO:0000313|RefSeq:XP_021564076.1};
GN   Name=ANKLE2 {ECO:0000313|RefSeq:XP_021564076.1};
OS   Carlito syrichta (Philippine tarsier) (Tarsius syrichta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae;
OC   Carlito.
OX   NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_021564076.1};
RN   [1] {ECO:0000313|RefSeq:XP_021564076.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_021564076.1; XM_021708401.1.
DR   AlphaFoldDB; A0A3Q0DM72; -.
DR   Proteomes; UP000189704; Unplaced.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd12944; LEM_ANKL2; 1.
DR   Gene3D; 1.10.720.40; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR   InterPro; IPR035006; LEM_ANKL2.
DR   InterPro; IPR003887; LEM_dom.
DR   InterPro; IPR011320; RNase_H1_N.
DR   InterPro; IPR037056; RNase_H1_N_sf.
DR   PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF01693; Cauli_VI; 1.
DR   Pfam; PF03020; LEM; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF63451; LEM domain; 1.
DR   PROSITE; PS50954; LEM; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189704}.
FT   DOMAIN          7..51
FT                   /note="LEM"
FT                   /evidence="ECO:0000259|PROSITE:PS50954"
FT   REGION          625..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          744..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          855..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   893 AA;  98046 MW;  ED4EDDE1560CBD0C CRC64;
     MTMDAILARL KLLNPDDLRG EIIKAGLKCG PITSTTRFIF EKRLAQALLE QGQLPSYPPD
     HDGAGAVAPS QDTQRVLKSA VENPTEQTSF SEDRDFGYSM GLNPPEEGAV IAKTCSVALS
     ATVDTLRAGV TASKEPPLYY GVCPVYEDVP ARNERIHVYE NKKEALQAVK MIKGSRFKAF
     STREDAEKFA RGISDYLPSP SKPSSPLSPV KVAPLFSNGG LKDGLCLSES ETVSKERANG
     YKNPRTQDLT AKLRKAVEKG EENTFSDLIW SNPRYLIGSG DNPTIVQEGC RYNVMHVAAK
     ENQASICQLT LEVLENPDFM RLMYPDDDVA MLRKRIRYIV DLYLNTPDKI GYDTPLHFAC
     KFGNADVVSV LSSHPLIIKN PRNKCEKTPE DVICERSKNK SVELKEKIRE HLQGHYYVPL
     LRAEDTSPVI GELWSSDQTA EVSHVSRYGG SPRDPVLTLR AFAGPLSPSK AEDFRKLWKT
     PPREKAGFFH NVRKSDPERG FERVGRELAH ERGYPWVEYW EFLGCFVDLS SQEGLQRLEE
     YLTQQEMGKK ACQGTRDEAA YCPHGAPTPG NNSISVRAFL DEDDMSLEEI KNRQNTALNN
     SQPALSAFAS SGCSTRSLGQ KADFIEAAEP RRAPSSRNGL CSRRSHSETP AGKRLEVPGG
     REAHPSPGSG LTAFDELSLQ NPGHGFSKTP SENIMETKDE KVLTPRTDAV ESDLLAPPAA
     AGQLGNNQRT ESEMSARIAK MSLGPSGPQR EAPLGCGPES QAVPPPVSPL ATREPAKRLF
     LFGEEPSKLD RDVLAALDCA HIDPRQYPAV HRWKNSVLCY SPSDRQSWSS PALKGKFKSQ
     LSDLGCTYSY SLGRSGATGS SPGKPGLGSP GRYSPAHGSP LRRMAHLTEL AAL
//