ID A0A3Q0DP01_CARSF Unreviewed; 1055 AA.
AC A0A3Q0DP01;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2 {ECO:0000313|RefSeq:XP_021564137.1, ECO:0000313|RefSeq:XP_021564138.1};
GN Name=FARP2 {ECO:0000313|RefSeq:XP_021564137.1,
GN ECO:0000313|RefSeq:XP_021564138.1};
OS Carlito syrichta (Philippine tarsier) (Tarsius syrichta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae;
OC Carlito.
OX NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_021564137.1};
RN [1] {ECO:0000313|RefSeq:XP_021564137.1, ECO:0000313|RefSeq:XP_021564138.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008048032.1; XM_008049841.1.
DR RefSeq; XP_021564137.1; XM_021708462.1.
DR RefSeq; XP_021564138.1; XM_021708463.1.
DR STRING; 1868482.ENSTSYP00000003316; -.
DR Ensembl; ENSTSYT00000003618; ENSTSYP00000003316; ENSTSYG00000003599.
DR KEGG; csyr:103251256; -.
DR OMA; HKHMPED; -.
DR OrthoDB; 2876516at2759; -.
DR Proteomes; UP000189704; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0022405; P:hair cycle process; IEA:Ensembl.
DR GO; GO:0016322; P:neuron remodeling; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0071800; P:podosome assembly; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0033623; P:regulation of integrin activation; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000189704}.
FT DOMAIN 44..324
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 537..728
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 757..854
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 931..1028
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 387..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 642..669
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 387..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 120561 MW; A46D7222D0D5F719 CRC64;
MGEIEGTYRV LQTAGTRLGA QTPVGVSTLE PGHTLSSRMQ EKHLHVRVKL LDNTVEIFDI
EPKWDGQILL TQVWKRLNLI ECDYFGLEFQ NIQSYWIWLE PMKPIIRQVQ KPKNAMFRLA
VKFFPPDPGQ LQEEYTRYLF AMQLKRDLLE ERLTCADTTA ALLTSHLLQS EIGDYDETLD
REHLKVNKYL PSQERFLEKI LEFHWKHMGQ TPAESDFQVL EIARKLEMYG IRFHTASDRE
GTKIHLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL
GSRDECKNFW KICVEYHTFF RLFDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYFKDGGM
KRIPYERRHS KTQMSIRTLT TDLPKQSISF TEGLRTSTSP SSANASFYPL PASPLTPPGL
PDFKNSSSSL TDTQVSYIKS PPAERSSGIM AGGPDTPSAQ PLGPPALQPG PGLSTDSPQP
SPSSQKSSLS LSPAFLVTLS PAEQGSSPLL SPVLSDAGGA RMDDEEEPRH KRVPADEAYF
IAKEILATER TYLKDLEVIT VWFRSAVVKE DAMPATLMTL LFSNIDPIYE FHRGFLREVE
QRLVLWEGPS KTHVKGGHQR IGDILLRNMH QLKEFTSYFQ RHDEVLTELE KATKRCKKLE
AVYKEFELQK VCYLPLNTFL LKPIQRLVHY RLLLRRLCEH YAPRHHDYAD CCDALKAITE
VTATLQHSLV RLENLQKLTE LQRDLVGIEN LITPGREFIR EGCLHKLTKK GLQQRMFFLF
SDMLLYTSKG VAGTSHFRIR GLLPLRGMLV EESEDEWSVP HCFTIYAAQK TMVVAASTRL
EKEKWMLDLN AAIQAAKSSS DTSPALPGST MCTHPSRSSN EVSLEQESEE DARGTRSSPE
GQGQHRANTT MHVCWYRNTS VSRADHSAAV ENQLSGYLLR KFKNSHGWQK LWVVFTNFCL
FFYKTHQDDY PLASLPLLGY TVSVPRETDG IHKDYVFKLQ FKSHVYFFRA ESKYTFERWM
EVIEGASSSP GRPPSLVQDC PRPSSGLEGQ SGKEE
//