ID A0A3Q0EQD0_VIGRR Unreviewed; 3740 AA.
AC A0A3Q0EQD0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC106756038 {ECO:0000313|RefSeq:XP_022634053.1};
OS Vigna radiata var. radiata (Mung bean) (Phaseolus aureus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX NCBI_TaxID=3916 {ECO:0000313|Proteomes:UP000087766, ECO:0000313|RefSeq:XP_022634053.1};
RN [1] {ECO:0000313|RefSeq:XP_022634053.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_022634053.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022634053.1; XM_022778332.1.
DR Proteomes; UP000087766; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_022634053.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087766};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1143..1767
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1980..2321
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3708..3740
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3545..3575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3587..3609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3740 AA; 418511 MW; 9A2143392D7CDD23 CRC64;
MQGIHQHQQH QHLAALVSAA LPKDDSDEDP SPRLAAIHSL HRAILHPHNS LLLSHSATFL
AQAFSQLLSD KCYEVRQAAV TAYGALCAVA ASIPVASNGR QNLLMLVDRF IGWALPSLST
AVAVDGTKEL ALEGLREFLN VGGTDRYALP ILKACQVLLE DERTSLALLH RLIGVITLIS
LKFVRCFQPH FPDIVDLLLG WALMPDLAQS DRRVILDSFL QFQKHWVGSL PMSLRLLTKF
LGDMEVLLHD GTPGTPQQFR RLLALLSCFS TILQSTASGL LEMNLLEQIC EPLSALLPRL
LRCLSMIGQK FGWSEWIEDS WKCLTLLAEI LQERFSSFYP LAVDILFQSL EFGVTVQRPG
LKKMSSFQVH GVLKTNLQLL SLQKLGLLPL SVKKLLKFDA SVSQLRLHPN HLVTGSSAAT
YVFLLQHANK EVVDEAVISL IEELELLKSL IGNNNGHSYE FNRIIDTKTF SEAELLALIK
FDLKVLLACV CMGEDNSLIK QKDIASLYLR RLEKLESFIT KQMNPFELPI QNFMELQITV
VKTLERLNSV EFLIKCSVRE ENCEKTLVEF PTEKEDRDDQ FSNERLAVIT EHLEKYSKLV
VKAFHVSSPL AIKLIVLDWG QKFCESVMAV NKISSISGFS YEACEYASVI MNLVFSLLGG
TFEREQEVRS HVAITLEMFM QAKLLHPVCF YPLAEVILEK LGDPTIEIRD AYVRLLAHIL
PTTIYTCGLY DYGRFRSVDP VLGNNSKLHW KQLFALKQLP LQLHSQHLVS ILSYISQRWK
VPLSSWIQRL IHSCQSSKDA ILSLPEETGI FGANSPWLDI RVDEDILEKI CSVNNLAGAW
WAVQEAARYC IATRLRTNLG GPTQTFAALE RMLLDIAHLL QLDNEQSDGN LSMIGSSGAH
LLPMRLLLDF VEALKKNVYN AYEGSVILPP ATRQSTLFFR ANKKVCEDWF SRICEPMMNA
GLAVHCNDAV IQYCTLRLQE LKNLSVSTLK EKSRTQVTDN LHNIRGRYKG DVLKVLRDVS
LALCKSSDPE SLIGLEKWVS ITFSLLGDEN QSFSEGGTVG PLSWISGLIY QARGEYENAA
AHFTHLLQTE ESLSSLGSDG IQFVIARIIE SYTAVSDWRS LETWLLELQQ LRAKHTGRSY
SGALTIAGNE VNAIHALARF DEGDYQAAWS SLDLTPKSNN ELTLDPKIAL QRSEQMLLQS
LLFQKEEKSD KVLHDLQKAR SMLEEPLSVL PLDGLAEATP LAIQLHCIFL VEDNCKLKTN
HEKAKQLPSI LNSLESLPSS ISKIRQDCNP WLKVLRVYKT ISPSSPVTLK FCINLHNLAR
KQNNLLLANR LNNYIKDHVF ACPEERHRNL LVLNLQYESI LLQYAENKFE DAFTNLWSFL
HPCMVSPKPS IISDVKERIL KAKACLKLSD WLRRDYSDWS PEGVVLKMAA DFDLAESSPC
GKDGSKENLS CKSNLGSIIE EIVGTTTKLS SRICPTMGKS WISYASWCFK QARDSLHVHS
ETILHSCSFS SMLVPEILPD RFKLTEDEVR RIKSLVLCLF QDNIDMKGFT DEQEERSSWL
DSAELSISES PLQKLVWNIV NVIETAAGAS GAENSGGECL SDMVSSQLRI CLLSTNFGLG
ESDITSALDN FVDIWWSLRR RRVSLFGHAA HGYIQYLSYS SSRICHSQVP GSEYETLKQK
AGSYTLKATL YILHILLNYG VELKDTLESA LLVVPLLPWQ EVTPQLFARI SSHPEQVIRK
QLEGLLTMLA KQSPYSIVYP TLVDVNAYEE KPSEELHHVL GCLRELYPRL VQDVQLMINE
LGNVTVLWEE LWLSTLQDLH TDVMRRINLL KEEAARIAEN VTLSQNEKNK INSARYSAMM
APIVVALERR LASTSRKPET PHEAWFQEEY KDQLKSALVS FKIPPVSSAA IGDVWRPFDS
IAASLASYQR KSSVSLGEVA PHLSLLSSSD VPMPGLERQM QVPDSDKATD HQGVVTIASF
HEQVTILPTK TKPKKLGILG SDGQKYTYLL KGREDLRLDA RIMQLLQAIN GFLHSSSSAC
SNSLTIRYYS VTPISGRAGL IQWAGNVVSI YSVFKSWQTR VQLAQFLALG SANTKSSAPP
PVPRPSDMFY GKIIPALKEK GIKRVISRRD WPHEVKCKVL LDLMKEVPRH LLYQELWCAS
EGYKAFSSKL KRYTGSVAAM SMVGHVLGLG DRHLDNILID FCNGDIVHID YNVCFDKGQR
LKIPEIVPFR LTQIIEAALG LTGIEGSFRS NCETVIGVLR KNKDVLLMLL EVFVWDPLVE
WTRGDFHDEA AIGGEERKGM ELAVSLSLFA SRVQEIRVPL QEHHDQLLTS LPAVESALER
FGDVLNKYEL TSSLYCRADQ ERSTLILHET SAKSIVAEAT SNSEKIRASF EIQAREFAQA
KAMVAEKAQE AMTWAEQHGR ILDALRWVPL TVVPEPTQAQ CHDIDREVSQ FIAELGDGLT
SATASLQAYS LALQRILPLN YLSTSAVHNW AQVLQLSINA LSSDMLSLAR RQASELIAKL
HVDNSDSIKF SHDDLCFRVE KYAVEIEKIE KECAEIESSI CSESESKTKD RLLYVFMKFM
QSIGLLKKEV GNSSVQSKYD SEMNNARPLG ELEEEREKVF SILNIAVSSL YSEVKHTILN
IYNDTSGGRN QYNMLQNDSG TIFAEFEEQV EKCNLVTEFV HDLCQFIGKD IPSVDINQVR
LKIFSESNWV SIFSNILISC KGLISQMTEV VLPDVIRAAV SLNSEVMDAF GLISQVRGSI
ETALEQLMEV EMERVSLIEL EQNYFVKVGL ITEQQLALEE AAVKGRDHLS WEEAEELASQ
EEACRAQLDQ LHQTWNQRDI RTSSLTKRET DIKNALVSVN CQFQSLVGVE EERELHILRS
KALLASLVKP FLELESIDIL LSSTDGSVAM PTSKFHTLTD LINSGNSISE YVWKVGGLLD
NHSFFIWKIG VIDSFLDACI HDIASSVEQN LGFDQSLNFM KKKLEIQLQK HIGHYLKERV
APSLLACLDK ENEHLKQLTE SSKELALDQG KKDGAVKKVI LMLEEYCNAH ETARAAKSAA
SIMKNQVSEL KEALRKTALE VVQMEWMHDV SLNPSYNRRI RFEKYLDTDD SLYTIILNLN
RSKLLDNVQS AVSKITTSMD CLQSCERNSL IAEGQLERAM AWACGNSSNS GNTSTTNSGI
PPEFHEHIKN RRQILWESRE KASDIVKLCV SVLEFEASRD GYLFIPDQPY PFRSSVDAKT
WQQVYLNALT RLDATFHSYS RTEQEWKLAQ CTVEAASNGL YTASNELSIA SLKAKSASGD
LQNTVLSMRD CAYEASVTLS AFARISRIQT ALTSESGSML EEVLAITEDI HDVYNLGKEA
AGIHLSLMEG LSKANAILFP LESVLSKDVA AMADAIDRES ETKKEISHIH GQAIYQSYCV
RIREACQNFK PLVPSLMLAV KGLYSLLTRL ARTANVHAGN LHKALEGIGE SQEVKSVTTT
LSRSDGGGDD AVEFDGKEGV GLYRSEDDKT DDFIGFSRLS LEDKGWISPP DSIYCTGSGS
DMTATEVSLP DSLNDSAGNK ELLSQGSSSR NPTGHMHTAV FSQTEVEEIS PFGLSQSSPA
ETDLNGSGSV KSINEATEHS EAIVVLGDKT AAIPANSQNP TNKNIDKFDS ADEPLSAKEI
KNATEHRDAR DLNVNANTRV GRGKNAYALS VLRRVEMKID GRDISESREI DITEQVDYLL
KQATSVDNLC NMYEGWTAWI
//
