ID A0A3Q0FI03_ALLSI Unreviewed; 1828 AA.
AC A0A3Q0FI03;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho GTPase-activating protein 23 isoform X2 {ECO:0000313|RefSeq:XP_025046899.1};
GN Name=ARHGAP23 {ECO:0000313|RefSeq:XP_025046899.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025046899.1};
RN [1] {ECO:0000313|RefSeq:XP_025046899.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025046899.1; XM_025191114.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 129..239
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 933..1047
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1142..1334
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1365..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1545..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1615..1646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1682..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1724..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..282
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1625..1646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1767..1806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1828 AA; 201235 MW; 21A0871F2CF225EE CRC64;
MVEEGAGGGD RASRGRQWGP PRPCAAPKMV GKALWSVERA KKGWCFERAI GVDCSSPEPR
CIWLTTLRTD NVDLERRWPR AGAAVTRQKC RSRPRVEKCR MPTPGRRDGA SPNANAPLEE
SFPWVGPKTV VLRKSPQGGF GFTLRHFIVY PPESAVHSNV KEEENGNPAG PQRSRLEPMD
TIFVKNVKED GSAHQAGLRT GDRLVKVNGE SIIGKTYSQV IALIQNSDDV LELSIMPKDE
DILQLAYSQD AYLKGNEPYA GGAQSIPEPP PVCYPRKTYP FQSRPPPREV MVAEPLQGQQ
ADSRPYRPSS SGPSSPMHST SLTSPTPSSW NEARSEAPRE FGSTHSSPAH RTEEIQYGMT
QQRAGMPLGR PAPAPGTFSH VSSSSCQGPL APSLPERYGV PPASSMTNHT CYGVPKHPPE
HRTHCGFKDA RDTSVVAAGM GRPSWEGSGG TKAVSRLECQ QALSNWISNQ VPRRSASEER
RYAMPPRYRS VSQDRLGDAP APRGWPHSAS QDTLLQPSHD SWAYRARSDN YLVRYGRSME
ALEQSALVSP RLDQCVWPPE KFYRPNHGQV ARTQPSQPSS YAPSSSSSRE APPMYVQKHP
SQPNLQSVDD SGYIGYRSYS PSFQRRTGLL HALSFRDPTF GGLPTFSISQ RQGNQPAPYT
DRSTPGLSTS LPAAAPPRPD PTSGSGLEIP KDQRSTSHES SVRPLEPSSP QGMERLQPEA
EEKKEEVILR QKPPTGRKML PPLRQMNFVF PDDMKETDIC DPPVSSKGEM QVAERPARRV
APLAAPEDSL ASIPFIDEPT SPSIDLKAKH IPASSVVSSA MNSAPANTTS PSSPTFTFAV
SRHYSQDCSS IKASRRSSYL LAITTERSKS CDDGLNTFRD EGKILRRMPS RVPSLRMLRS
FFTDGSLDSL GTSEDTRSKR HSTSDLSDVT FSDVRKEGWL HYKQILTKKG KKVGGGIRQW
KRVFAVLRAH SLYLCKDRRE AVAYAAPQGE EEQPISIRAC LVDISYSETK RKHVFRLTTA
DFCEYLFQAE DRDDMLAWIK VIRENSKAEG EDPSFASQAL INKKLNDYRK VNPPGTKPDS
SPKGSRGLGI KPEFLKQTGT CAPRSPRQDM AVTKDESGSQ KAPWGINIMK KNKKSAPRAF
GVRLEDCQPA PDNKNIPLIV EACCKVVEDK GLEYMGIYRV PGNNAMVSSL QEQLNKGATE
INLQDERWQD LNVISSLLKS FFRKLPEPLF TDDKYNDFIE ANRIEDASER MRTLRKLIRD
LPGHYYETLK FLVGHLKTIA DHSEKNKMEP RNLALVFGPT LVRTSEDNMT DMVTHMPDRY
KIVETLIQHS DWFFSDKEDK GEKTPVDEKE AQSVPNIEYL LPNIGRTAAP GDASDSTNSS
STKSKGSWAS RKDQYHKEML TISFISAVNR KRKKRREAKR FGSSTDDDSE HEATKGAGKA
RGEEALGAER HGEAEEGEAE ELRDHDAPGE AGVEPDARSR VGPEVVCLQQ EGHLEVGLAE
AGGLKGMKMA VALRSSPEPA LDARSIVSGY STLSTIDRSL CSEVQSVAES RGEEADDERS
EFSHVETDTE SSFFPGRAGP HEGQGDVAGV GVSSDKDRRA SFSSRRLIQC DTLARKRLLR
PRRDSNSSAK GSAEAPSSSS RGSQESLLPL GAAAEKRGSW ASARPSLREQ LRLRLRGSAD
DMLAVPMRQP HSPETRRKKS SWRRHTVVVP GGLKDLNFNE WKEQRAPGQD LADGATSGAR
GSAEGRPPEA SASCKDLHRD NKDSGLSSLE STKARPSSSS SSSLLGNSAP SHQGGAGEQQ
HSKGTEGNPG DRGPAPKRTA SLHFHQCL
//
