ID A0A3Q0FI40_ALLSI Unreviewed; 403 AA.
AC A0A3Q0FI40;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Protein NDRG2 {ECO:0000256|ARBA:ARBA00015427, ECO:0000256|RuleBase:RU367129};
GN Name=NDRG2 {ECO:0000313|RefSeq:XP_025046939.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025046939.1};
RN [1] {ECO:0000313|RefSeq:XP_025046939.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC Down-regulates CTNNB1-mediated transcriptional activation of target
CC genes. May be involved in neuron differentiation.
CC {ECO:0000256|RuleBase:RU367129}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU367129}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000256|ARBA:ARBA00005598,
CC ECO:0000256|RuleBase:RU367129}.
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DR RefSeq; XP_025046939.1; XM_025191154.1.
DR InParanoid; A0A3Q0FI40; -.
DR OrthoDB; 5352016at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF17; PROTEIN NDRG2; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367129};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367129};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU367129};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|RuleBase:RU367129};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU367129}.
FT REGION 354..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 44166 MW; E5E3CD122DB6FB76 CRC64;
MTELHEVQIT EGKPLLVSPA QSEPGKDAEL LAARLSQDHG QKHSVETPYG LVTFTIHGTP
KPKRPAILTY HDVGLNRKXX XXXXXXXXXL FHYEDMQEIV KNFVVVHIDA PGMEDGAPVF
PIGYQYPSLD QLADMIPCIL QYLNFTSIIG IGVGAGAYVL GRYGLSHVDT VEGLVLINID
PNAKGWMDWA AHKLTGLTSS IPEMILAHLF SQEEISNNTE LIQQRREALS TAPNLSNIQL
YWNSYNSRRD LNLERGGDVT FKCPVMLVVG DQAPHEDAVV ECNSKLDPTQ TSFLKMADSG
GQPQLTQPGK LTEAFKYFVQ GMGYIPHILD RKLSQGGFLL HDAPVTVSHR LAHQRSLGRR
QPLSLAHPVP EQRVGGPADT CRPNHGGLLL SGGEAGDGDA SRL
//
