ID A0A3Q0FIB4_ALLSI Unreviewed; 713 AA.
AC A0A3Q0FIB4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Ena/VASP-like protein {ECO:0000256|ARBA:ARBA00017156};
DE AltName: Full=Ena/vasodilator-stimulated phosphoprotein-like {ECO:0000256|ARBA:ARBA00033193};
GN Name=EVL {ECO:0000313|RefSeq:XP_025046982.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025046982.1};
RN [1] {ECO:0000313|RefSeq:XP_025046982.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber
CC {ECO:0000256|ARBA:ARBA00004529}.
CC -!- SIMILARITY: Belongs to the Ena/VASP family.
CC {ECO:0000256|ARBA:ARBA00009785}.
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DR RefSeq; XP_025046982.1; XM_025191197.1.
DR AlphaFoldDB; A0A3Q0FIB4; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0001725; C:stress fiber; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR CDD; cd01207; EVH1_Ena_VASP-like; 1.
DR CDD; cd22185; WH2_hVASP-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR038023; VASP_sf.
DR InterPro; IPR014885; VASP_tetra.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF4; ENA_VASP-LIKE PROTEIN; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF08776; VASP_tetra; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF118370; Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 4..118
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 120..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..502
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 76541 MW; 671A94BAAF02BBC5 CRC64;
MYAFEEFSEQ SICQARASVM VYDDTSKKWV PIKPGQQGFS RINIYHNTAT NTFRVVGVKL
QDQQVVINYS IVKGLKYNQA TPTFHQWRDA RQVYGLNFAS KEEATTFSNA MLFALNIMNS
QDGGPTTQRQ VQNGPSPDEM EVQRRQVMEQ QQQQQQRQES LERRTSTTVS TLQIKVCSSP
SHCQSPPPDY SNCSAPTSAG PAPPPPSYAR AISSTSAAPK PSNKTSFRSS ARARDSPQLH
HRHSASELLP SSGSSPVLPS HRTVTQSIKQ ISLSPPPAPP SHFPLTPRQL VRRSSLSYSP
QLSSSLTVTS PVQKGFVLQP HIPVVLPVIP VQNGRIRGST GITVQEACAD VPQIGLNGQP
KGPLTTQIPL NSYRTQVESA DGSFFSYLET VPISQLPVIQ APSQSSQTSP HPPQQLYQSM
SHFVSLPPTY AAVSEVNMSK RTPPYMSSST ISQLSPILPP GHPSAAAAIP ASSSGPPPPP
PPPVPPPPMG AAPPPPPPLP AGGAQGAGSD DGSTSGFAAA LASAKLRRVQ RPEDGSGGSS
PCGASKSDAN RTSSGGGGGG LMEEMNKLLA KSLSRRKAAS QSDKPADKKE EESQNEDAST
SPLPVTRGPS QPQNSSEPGK KPWERSNSVE KPVSSLLSRN PSVTKSPDVK SPVQSQPPFR
MKPVSSSNDV AMDALDFDRM KQEILEEVVR ELHKVKEEII DAIRQELSRI STT
//
