ID A0A3Q0FMX7_ALLSI Unreviewed; 1707 AA.
AC A0A3Q0FMX7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=FERM and PDZ domain-containing protein 3 isoform X2 {ECO:0000313|RefSeq:XP_025049001.1};
GN Name=FRMPD3 {ECO:0000313|RefSeq:XP_025049001.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025049001.1};
RN [1] {ECO:0000313|RefSeq:XP_025049001.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025049001.1; XM_025193216.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13183; FERM_C_FRMPD1_FRMPD3_FRMPD4; 1.
DR CDD; cd17169; FERM_F1_FRMPD3; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR049385; FAK1-like_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041779; FRMPD1/3/4_FERM_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46221:SF1; FERM AND PDZ DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF21477; FERM_C_FAK1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 13..90
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 139..453
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 140..238
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 484..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1707 AA; 189653 MW; 86E7CD057D9DDE0A CRC64;
MECGQLPSDI LRQVKIQRDP NYGFGFVAGS EKPVVVRSVT TGGPSEDKLL AGDQILAIND
EDVSEAPRGR FIELVRSAKD FIILTVLQTH QSPKSAFISA AKKAKLRSNP VKVRFSEQVT
VGETDPDMLK KEALLLIPNV LKVFLENGQI KSFTFDGRTT VKDVMVTLQD RLSLRHIEHF
ALVLEYSSPE QSHKFLLLQD KQPLAHVVQR THYQGMRCLF RVSFFPKDPV ELLRRDPAAF
EYLYIQSRND VIRERFGMDP KPEMLLGLAA LHIYITVAAT RPSQKVSLKN VEKEWGLEPF
LPPSLLQLIR EKSLRKSLSQ QLKAHQNQPP GGSKVSTTQA KLQYLRILNE LPTFAGVLFN
TVGLDEKQPA TTLLVGPRHG ISHVIDLKTN LTTVLSEFSK VSKIQLFREN QGVARVETSI
LDAKPLVLLM EWPEATNFAC LIAGYCRLLV DSKKMIFSRP PSQPPPPQII KADYINAHNI
HRPTATGHVG KKESGFLGGA ASGPGEPNPR VSKASDSELV SFCYLHMREQ RKERENRTDI
NENLIFFEET RPRTKSDPTS KSSGQGYDSA ANEYNPDGLD RDRHAMRARA NTMDSHTRND
TMHFYCDSCK TKIKSRLASR KGSKPGSSRD NMVDLMSLPP PGSDEEEDET TALLPAIAAP
PPGFRDNSSD EDDPKRRAAA QSQEQGRHLC GILYDEIPVT LIDSVQTRTV RDHAQELDDA
LVSTLQALEA LAASEDCPHP QPQQTAGLIV LAAITPESSL DSGHETNSSE LTDVSEMVSA
MKQHQNAAYF LAQHINKENL LTRKDLPFRI QSCTAQAVLT SPYPLARQEP GPSLKPAFSN
QSPNLTNGRS KQEQQHMERS YTLAVQPMLS PQLNEQNRSV LVPGSECKGA SLSKAAFEVS
LHAAAAALSG EQVKDLREKI PKEVRLSPKL ILDPKSGMTP AIISAALQQA ANSKGLPSQG
AATMATLKED KQTNGTKSCE ASSSKHLKLK GSELAIETLC NCQQQQQPQQ QQPQQPQDEA
CPSPKESASS RVEEFHLSPV GNEKLPTKSF PSKSYQQKGS QDPSGKPASR EASQKAGSDA
TNYAFQKHFV PSNQGENTQH ESSVKSFKAE SSGLLSASPS STFRTTSEDP KGQIQLVPRS
ESLQISTVPS KKSEKVLEVT SPDVDVPAKP KVPKAPFRLK NLFSATFPTR LKKETDERQA
QLQKVKQYEL EFLEELLKPK TKGDVPPQEY LHPSIPGRCS CQLRSSPVQK VPGMSREQRR
SCDCKRICRG VRPLPNQLVA PEAERQGREK ATDDQKQTEA VRLSSTSSPS NGRRIRSMSL
ESRDCRSDPE NSVSCLTTCT SRGECMGAPH YKKLMRHYSV SEIDKTDRTS LSSDIYQNVY
PAKQKGLQKE VDPSIHGSAL KSKVQESPRG GDPSYVQIAQ EKKNQKSSAV FSVQEEMYPS
HAELQDEDME DEKCCSIRYC FYYRKCDVAD DGSEKDELSY SIPMQILPGM KLENQLVPVM
SRTLQVLDAT ACSSPDDSQT QEIDLRTSTF EGSLAKISAL RGHVYSLPDG FLQVQLDTNE
LLTILRQCVV SPELWDCKTY ISQLAEYKQE LALKFKEFRA SCRRVAAVDK SPTHMLSAIT
SSFQVLGSLI ETFVRLVYIV RSESQRQELL AKVEEVVRNY TFLLRAAEES TARTLSHHQT
EQLAHQSTTV ATVMSTFTRS LKTLINK
//
