ID A0A3Q0FNK7_ALLSI Unreviewed; 575 AA.
AC A0A3Q0FNK7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Mitochondrial sodium/calcium exchanger protein {ECO:0000313|RefSeq:XP_025048857.1};
GN Name=SLC8B1 {ECO:0000313|RefSeq:XP_025048857.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025048857.1};
RN [1] {ECO:0000313|RefSeq:XP_025048857.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_025048857.1; XM_025193072.1.
DR AlphaFoldDB; A0A3Q0FNK7; -.
DR STRING; 38654.A0A3Q0FNK7; -.
DR KEGG; asn:102374698; -.
DR InParanoid; A0A3Q0FNK7; -.
DR OrthoDB; 5482417at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..235
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 413..563
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 248..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 63706 MW; 870F8C0FE9417AB2 CRC64;
MVKLGREPRS FKSLSSALLT KPHCLLMITL RLGNPWLSMC HSACWEVRKQ NSSQWCSFIR
TNPDCQIDGG FLDYLDGVFC VFPSTLLPLA VTLYAMWLLY LFIILGVTAE KFFCPNLSAI
STNLRLSHNV AGVTFLAFGN GAPDVFSAVV AFSDPRTAGL AIGALFGAGI FVTTVLAGGI
ALVKPFTAAS RPFLRDAIFY MVAVFVTFLA LYFGSISLPW ALGYLGLYIF YVCTVVICTW
IHRRQRREGS STSSSREPEL VTESENGGST SSMNGADFGE EYRPLLPHEE KTLHILTKSL
NTLDYRKWRR KPCYWRLFEV FKMPIEFVLL LSVPIVDPDK EDRNWKRPLN CLHLITSPLV
CILTLKSGAY GLYKIQGVFP IWGMVILTGA FLALVIFFTT KNREPPKYHC LFAFLGFLAS
AMWIKAAATE VVNILRTLGV IFQLSNTVLG LTLLAWGNSI GDTFSDLTMA RQGYPRMAFS
ACFGGIIFNI LVGVGLGCLL QMTSSQSVVK LEPDGLLMWI LAGALGLSLV FSFVSVPAQC
FHLGKAYGIC LLIYYLAFLT VALLTEFKVI ELTTL
//
