ID A0A3Q0FNU6_ALLSI Unreviewed; 563 AA.
AC A0A3Q0FNU6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
DE EC=2.3.2.27 {ECO:0000256|PIRNR:PIRNR015614};
GN Name=TRAF1 {ECO:0000313|RefSeq:XP_025049331.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025049331.1};
RN [1] {ECO:0000313|RefSeq:XP_025049331.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|PIRNR:PIRNR015614};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR RefSeq; XP_025049331.1; XM_025193546.1.
DR STRING; 38654.A0A3Q0FNU6; -.
DR KEGG; asn:102377947; -.
DR InParanoid; A0A3Q0FNU6; -.
DR OrthoDB; 2913784at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd23125; RING-HC_TRAF1-like; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR032070; TRAF_BIRC3-bd.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF96; TNF RECEPTOR-ASSOCIATED FACTOR 1; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 2.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614};
KW Receptor {ECO:0000313|RefSeq:XP_025049331.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 41..81
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 133..185
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 398..559
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 133..185
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 63352 MW; EB316CDFF3B3A1A7 CRC64;
MAEKATRGTQ DVPSSSPDEN EFPFGYPTSI SEDVPDAKYL CSNCNNILKK AMQTLCGHRY
CLACLSWIVR NNKNPVCQKC KEEDPGMLNE GSVLAEERAF SDAAINKEIS ELKVHCGTSG
CNWSGIMKNF EEHQSLCEYA LIPCHTGCGQ MVMRKKLADH LENGCVNNMT TCQKCKQMLS
SNEYQKHTCT GNSVKEQKRT HPDASSKEKQ NRSAPFNSKD GCRFSEVGCS FRGGKEKTKE
HEKTSVGAHL LLLLQHIKQL RACLCPAESK VKSLERKVSD LQVPGASEIN GDLEVDCFPL
SSLVEEESTL QRLVKEKMIS ELESKLQVFE NIVAVLNKEV ETSHLEIAAF RRQSELDQNM
IRNLELKIAE LHRCLTQKDT GLSRLHKSLQ CSEQASYDGV FLWKIMDVXX XXXXXXXXXX
XXXXRKLQDS VTGRTISLYS PAFYTGKYGY KVCLRIYLNG DGTGKGTHVS LFFVVMKGDY
DALLPWPFKH KVTFMLLDQN NREHVIDVFR PDLNSASFQR PVSDMNIASG CPTFLPLSKL
QSPKYAYVKE DTIFLKCIIE TNS
//
