ID A0A3Q0FRX4_ALLSI Unreviewed; 1475 AA.
AC A0A3Q0FRX4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Protein crumbs homolog 2 isoform X2 {ECO:0000313|RefSeq:XP_025050037.1};
GN Name=CRB2 {ECO:0000313|RefSeq:XP_025050037.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025050037.1};
RN [1] {ECO:0000313|RefSeq:XP_025050037.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_025050037.1; XM_025194252.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 17.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 19.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF00008; EGF; 14.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 18.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 13.
DR PROSITE; PS50026; EGF_3; 20.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1475
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018178925"
FT TRANSMEM 1415..1438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..73
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 75..113
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 115..152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 154..190
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 192..228
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 230..266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 268..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 306..343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..381
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 383..439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 441..477
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 522..562
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 564..750
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 752..788
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 794..970
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 972..1008
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1034..1209
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1211..1247
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1249..1284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1286..1322
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1326..1363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1365..1401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 84..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 103..112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 142..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 180..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 218..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 256..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 294..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 371..380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 429..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 467..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 552..561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 778..787
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 998..1007
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1237..1246
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1253..1263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1274..1283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1312..1321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1353..1362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1391..1400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1475 AA; 158407 MW; 985D5C9F48572FE2 CRC64;
MLAMELKRII SRAYHAAALL PVFLLLWGST CTEDVKSCSS SPCQNGGSCE DLGRGYRCVC
PQQPLAYTGT NCELLYDACA VHACSTNKTC RTVPGLQEYE CICRPGFTGI DCSVNINECE
SNPCKEPHFE CVDSVNGYTC QCQTGLTGEG CQTAISLCSS HACLNNGTCV QSAEDYVCFC
LPGFTGDHCE HDVNECASSP CQNGAICRDM VNEYKCFCVP GFQGYRCEID INECASRPCK
NNGTCRNERD HYICECVPGY TDVNCDAEIN ECDSDPCENG GTCSDHIGFF TCTCAPGYEG
VQCEVDINEC LSQPCNNGGK CLDLVNSYQC DCSDTGFEGE HCELDILECA SQPCLNSATC
LEGVKNYSCA CWPGYMGQRC EEDVDECATE PCHNGGVCFE RSNQSYYGTQ PDFPHEFNYS
QAAGFLCWCQ PGFEGETCSV NIDECESQPC QHGARCEDLV NSFLCHCPPG YSGVECAVDI
NECEDGPCEN GAACEDGIAD YTCRCVPSQN GTVWGGKNCS IQLTGCQTHD CQNEALCTPT
YVAGSHGHLC QCQPGFYDAT CSTPTTFSFA SRTFLPIDMS TGDWSRKDGA GVPVASVSLR
FRTTLPDAIL FYRGQEEAYL FLELSGGTLH AGVQRNNSKS SLALEGLKVD DGQWHKAEVL
LQDSVELKLW HESCDAGVCL QSAVVGDSAT LLPPAFLKAY VGGVDGSGIA NTTRSRQGYI
GCLQDLQVDS QAVLPLDLLP NASSLAALGC DRTEWCQAQP CSHGGSCVDL WATFRCNCSR
PYEGLTCSYE YPAATFGLED SSSFASFTLA DNPMADFSVS FFIRTLKPEG LVLQVHDGTG
PCLTVYLKDG RLLLETPSAG PMALSEALAD GKRHLVTLSS REGVAYASHS DREVELGHLG
VKPLAAGHEL YVGGLPQQES MGTWGGYFKG CLQDIQLNNH RLELFAHQAD NYSLPREAYM
GRTTGLMQGC ISDDTCKSKP CHNGGVCTVT WNDFSCSCPA NFTGKTCEER VWCESAPCPK
ATACVDVPAG YVCLANATFY GHAATEFTTN ASVTRTLSSV RLDFRTRDTD AILLRATEAV
GSLQIAIQNS SLLVEMSSGN SIEGASFRSR LPVTDGAWHT VSLTMEEPSA LSSRWLVHLD
SSMNATLQGR AGDLAFLRTN ALIVLAENFT GCLGEVTIGE IHLPFTAHLP YPQPEQFLQA
GGSAIQLGCT GADVCGSSPC LNAGTCEDLF DSFRCACSTG WAGPLCEANI DDCQASPCVH
GTCVDLVADF QCECAPGFVG KKCDVDVDDC GQHQCLHSGT CVDEVAGYSC KCLPEYSGPR
CEWPFPPEQC GKNFTCLNGG KCTSGPWGAN CTCKPGFTGR NCQININECD PNPCQNGGTC
QDAVNKYECV CSASYTGEHC DIDQPVWAHL SNSSVVGAVG AAGAALLLAV IAGSVIAMKK
RRATQGTYSP SRQEKDGARV EMWNVIKMPP TERLI
//
