ID A0A3Q0FS75_ALLSI Unreviewed; 583 AA.
AC A0A3Q0FS75;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Pescadillo homolog {ECO:0000256|HAMAP-Rule:MF_03028};
GN Name=PES1 {ECO:0000256|HAMAP-Rule:MF_03028,
GN ECO:0000313|RefSeq:XP_025048538.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025048538.1};
RN [1] {ECO:0000313|RefSeq:XP_025048538.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and
CC WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and
CC WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
CC {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000256|HAMAP-
CC Rule:MF_03028}.
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DR RefSeq; XP_025048538.1; XM_025192753.1.
DR AlphaFoldDB; A0A3Q0FS75; -.
DR STRING; 38654.A0A3Q0FS75; -.
DR KEGG; asn:102372363; -.
DR InParanoid; A0A3Q0FS75; -.
DR OrthoDB; 169151at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03028};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03028};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03028}.
FT DOMAIN 324..417
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 448..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..482
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_025048538.1"
SQ SEQUENCE 583 AA; 68258 MW; E4AE246DA05FFA65 CRC64;
RIFVLVPPKY ERGSATNYIT RNKARKKLQL SLADFRRLCI LKGVYPHEPK HKKKVNKGST
AARTFYLLKD IKFLLHEPII NKFRDYKVFV RKLRKAYGKS EWNTVERLKD NKPSYKLDHI
VKERYPTFID ALRDLDDVLS MCFLFATFPR TGKCHVQTIQ LCRRLTVEFL NYIIASRCLR
KVFLSIKGIY YQAEVMGQLI TWITPYAFAH DHPTDVDYRV MATFTEFYTT LLGFVNFRLY
QSLNLHYPPK IEGQAEVELK PKEGEAYALN SESYVEKLSA LSASLARVVA PNPEDEVEID
EFPVDGESAE HEEARRKEQE SLEKQKKLFE GLRFFLNREV PREPLAFIIR CFGGEVSWDK
SVCIGATYDV TDPTITHQIV DRPNLEKQVI SRYYLQPQWV FDSVNAKMCL PVADYFPGVL
LPPHLSPFVA EKDGDYIPPE KLKLLALQRG ENPEEEEEEE EEEEEGGEED DDGSEEEDDS
EKEEEEKLKR MEEQKTQGKK LPVKVTVGTV RLEDKQRRVQ EEQNEEKRLA IMMMKKKEKY
LYQKIMFGKK RKVREANKLA EKRKAHDATL KLEKKKTKKA RRE
//
