ID A0A3Q0FWA8_ALLSI Unreviewed; 679 AA.
AC A0A3Q0FWA8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PAK5 {ECO:0000313|RefSeq:XP_025050023.1,
GN ECO:0000313|RefSeq:XP_025050024.1, ECO:0000313|RefSeq:XP_025050025.1,
GN ECO:0000313|RefSeq:XP_025050026.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025050023.1};
RN [1] {ECO:0000313|RefSeq:XP_025050023.1, ECO:0000313|RefSeq:XP_025050024.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006037862.2; XM_006037800.2.
DR RefSeq; XP_025050023.1; XM_025194238.1.
DR RefSeq; XP_025050024.1; XM_025194239.1.
DR RefSeq; XP_025050025.1; XM_025194240.1.
DR RefSeq; XP_025050026.1; XM_025194241.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06648; STKc_PAK_II; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF27; SERINE_THREONINE-PROTEIN KINASE PAK 5; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|RefSeq:XP_025050023.1,
KW ECO:0000313|RefSeq:XP_025050024.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transferase {ECO:0000313|RefSeq:XP_025050023.1,
KW ECO:0000313|RefSeq:XP_025050024.1}.
FT DOMAIN 11..24
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 453..679
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 483
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 679 AA; 77008 MW; F546F5D52C403901 CRC64;
MFGKKKKRLE ISGPSNFEHR VHTGFDHREQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT
PIQLAPMKTI VRGNKPRKDT SINGLLEEFD NISVTRSNSL RKESPPTPHQ GNSNHVQSHQ
EENGYLTYSQ YSSESDATTD YVTDKHRDKS LFGEELDRYC KGSYAMKQNG HMIKTKPTDA
YYSEVKPLKS DILRFLPDYN THMETKSKPI EYGGLKLEYQ RVPSGSTLDY REPFHYAPSR
TSVQSECSKE RLEYSDSDWG SGPGKDDYEK RPKSSYVNQA SPQPTMRQRS RSGSGLQEPV
MPYGASAFKS NQQGHSYSSY TYPRLSETAA GIPKVDYDRA QMVVSPPLSG SDTYPRGPTK
LPQNQNKVSY TSPGYQYPSV YHKAVHYHQP SFQSSSHYIS TASYPSSPSI TSSAYPPPSW
VSSSDQQPSR VSHEQFRAAL QLVVSPGDPR EYLDNFIKIG EGSTGIVCIA TEKHTGKQVA
VKKMDLRKQQ RRELLFNEVV IMRDYHHENV VDMYNSYLVG DELWVVMEFL EGGALTDIVT
HTRMNEEQIA TVCLSVLKAL SYLHNQGVIH RDIKSDSILL TSDGRIKLSD FGFCAQVSKE
VPKRKSLVGT PYWMAPEVIS RLPYGTEVDI WSLGIMVIEM IDGEPPYFNE PPLQAMRRIR
DNLPPRVKDI HKVRMLIFP
//
