ID A0A3Q0FWH8_ALLSI Unreviewed; 556 AA.
AC A0A3Q0FWH8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=T-kininogen 2-like {ECO:0000313|RefSeq:XP_025051699.1};
GN Name=LOC102372524 {ECO:0000313|RefSeq:XP_025051699.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025051699.1};
RN [1] {ECO:0000313|RefSeq:XP_025051699.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
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DR RefSeq; XP_025051699.1; XM_025195914.1.
DR AlphaFoldDB; A0A3Q0FWH8; -.
DR STRING; 38654.A0A3Q0FWH8; -.
DR KEGG; asn:102372524; -.
DR InParanoid; A0A3Q0FWH8; -.
DR OrthoDB; 5223498at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 3.
DR Gene3D; 3.10.450.10; -; 3.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR027358; Kininogen-type_cystatin_dom.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR13814; FETUIN; 1.
DR PANTHER; PTHR13814:SF12; KININOGEN-1; 1.
DR Pfam; PF00031; Cystatin; 3.
DR SMART; SM00043; CY; 3.
DR SUPFAM; SSF54403; Cystatin/monellin; 3.
DR PROSITE; PS00287; CYSTATIN; 1.
DR PROSITE; PS51647; CYSTATIN_KININOGEN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasodilator {ECO:0000256|ARBA:ARBA00022429}.
FT DOMAIN 46..150
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT DOMAIN 161..263
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT DOMAIN 275..378
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..454
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 61892 MW; 10838719E04598CE CRC64;
MPQPSKPRPR RGHNPANCGP TVTADRGWNF RLEDRASPLP SEDVDCDHPE VFEAVDIALR
KYNDDKTDGN QFALYMVTDA QRTAGPGAQF FVKYQIREST CAIGEGKAWQ DCDYNASVEA
ETGECTAEVY IDKTQKISNV SQECKIIPAR MCVGCKHPIG SDSPDLLPIL KLAVQNFNKR
SVKRFLYDVG EIIKATSQVV DGINYEVEYK IKETNCSKHE YQDLHAECKP SFGALEGRCE
AKAFVDLNNT IASIIEKCMF PDPPFCAGCP VPIPVDSPEL EEVLKVSMEK YNSESNTDFY
YKIKSVYHAT VQVVAGKNYE IHFNIQKTNC SKSEVEKLNE DCEAEIGSMP LECTANIYVV
PWKQEIFPQV NCSAALMGHY GYRNGFTPFR SSMEHEIGPG RANEDGQRAG HACRVGSCSH
EHGHGHQFKH RPGHKRGHEI GCGHKKHHKK DKHKDSKDKS SEESEEKVPC QRESQPPSVD
EGLFQSDALT TPAVTVGPRD DSSTPDIPVE PVSPATVETT PDISLFHELP DHPESPVPKC
PGKPWKSVMQ LTNPSE
//
