ID A0A3Q0FX18_ALLSI Unreviewed; 605 AA.
AC A0A3Q0FX18;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Kinesin-like protein KIF22 isoform X2 {ECO:0000313|RefSeq:XP_025050288.1};
GN Name=KIF22 {ECO:0000313|RefSeq:XP_025050288.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025050288.1};
RN [1] {ECO:0000313|RefSeq:XP_025050288.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR RefSeq; XP_025050288.1; XM_025194503.1.
DR AlphaFoldDB; A0A3Q0FX18; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01376; KISc_KID_like; 1.
DR Gene3D; 1.10.150.280; AF1531-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR24115:SF1000; KINESIN-LIKE PROTEIN KIF22; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF12836; HHH_3; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 20..340
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 344..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..458
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 99..106
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 605 AA; 67184 MW; FF914DB838566F86 CRC64;
MQSQPRPSMK EHRQPDAPVP VRVCVRLRPC SKDSEPCVRG LDSRSLELVN WRNAKETFKY
QFDTFYGDTA TQQDVYCSSV QPILHHLLQG QNASVLAYGP TGAGKTHTML GSPQQPGVIP
RAVRDILHMV REAGCGPDGH NCSYSVSMSY LEVYQEKVLD LLEPSGRDLV LRETPDRSIM
VTGLTEQELS SFHDFEKHFL LASRNRTVAS TGLNSRSSRS HAALVLRVAQ SRPLVPARSA
KLQLVDLAGC EDNRLTGNCG LRLRESSVIN TSLLVLGKVV DALRLGRPRV PYRDSKLTRL
LQDSLGGSAH SVVIAHVAPE QRFYFDTLTT LNFATRSKQV VNKPFAPGAL PEPAAEKTLQ
KENSDKQKQS TSKEGPLVAE KPLGALLPLD QLEPSLVQRV LRLEELERQQ GAGHRGLPLL
GTPKAERKAL LRCLEETQAE LEMRQQQKEL EAKELLRAAS TPEPPQAIVL PMRQVPIPQK
RAPPTEDEGI LVLKRRSDPG GTENAVPSWE LTRCQELMVR GHQKLLELLN QGSTRELLSL
KRIGPRTAEL IMAWREQHGP FVTLQDLQRM ETMTAKKVAT LIKANTLDCI QMLLPPGPSA
LSLFS
//
