ID A0A3Q0FY34_ALLSI Unreviewed; 1994 AA.
AC A0A3Q0FY34;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRS {ECO:0000313|RefSeq:XP_025052264.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025052264.1};
RN [1] {ECO:0000313|RefSeq:XP_025052264.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR RefSeq; XP_025052264.1; XM_025196479.1.
DR STRING; 38654.A0A3Q0FY34; -.
DR KEGG; asn:102368005; -.
DR InParanoid; A0A3Q0FY34; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14627; R-PTP-S-2; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_025052264.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 63..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..182
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 194..292
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 300..382
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 389..479
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 484..578
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 582..671
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 676..773
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 778..886
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 887..984
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 985..1084
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1086..1177
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1439..1694
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1614..1685
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1726..1985
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1903..1976
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 20..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1357..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1994 AA; 223086 MW; BCC5729DE9EE935E CRC64;
MEVATWPRSC TLFELSKDSL PNSAPASARP GGEGADVASE TPRALLTWSL SGGGRRSLPR
MRILSGPGMP SFIPLVTLLS LLLIACVAES PPVFIKKPVD QIGVSGGVAS FVCQATGDPK
PRVTWNKKGK KVNSQRFETI EFDESAGAVL RIQPLRTPRD ENIYECVAQN LHGEVTVQAR
LTVLREDQLP PGFPNIDMGP QLKVVERTRT ATMLCAASGN PDPEITWFKD FLPVDPSASN
GRIKQLRSET FEGTPIRGGL QIESSEETDQ GKYECVASNS AGVRYSSPAN LYVRVRRVAP
RFSILPVSHE IMPGGNVNIT CVAVGSPMPY VKWMQGAEDL TPEDDMPVGR NVLELTDVKD
SANYTCVAMS SLGVIEAVAQ ITVKSLPKAP GTPMVTETTA TSITITWDSG NPDPVSYYVI
EYKSKSQDGP YQIKEDITTT RYSIGGLSPN SEYEIWVSAV NSIGQGPPSE SVVTRTGEQA
PASAPRNVQG RMLSSNTMII QWEEPVEPNG QIRGYRVYYT MEPDQPVSNW QKHNMDDSLL
TTVGSLLEDE TYTVRVLAFT SVGDGPLSDP IQVKTQQGVP GQPMNFRAEA KTETSILLSW
SPPRQEIIVK YDLLFREGDH SREVSRTFDP ATSFMVENLK PNTEYVFRLA ARSDLGLGAF
TPEVRERTLQ SKPSAPPQDV KCVSTRSTAI LVSWRPPPAE SQNGVLVGYS IRYRALDSED
TELKEVNDIP PTTNQILLES LEKWTEYRIA VVAHTEVGPG PESSPVIVRT DEDVPSAPPR
KVEVEVLNST AIQVFWRSPV QNRQHGQIRG YQVHYVRMEN GEAKGLPQIK DVMLADAQWE
TDDTAEYDMI IAGLQPETAY SITVAAYTMK GDGARSKPKL AMTKGAVPGK PILSVHQTQE
NALLVKWEPP LEAEGQVMGY RLQFGRQDIA PLATLEFAAQ EDKYTAVNIH KGATYVFKLA
VKSRAGFGEE AVQELTIPED IPKGYPQILE ASNISSMSVQ FGWLPPVLAE RNGAIVKYTV
AYWEAGSPSN LLEKDLPPSP ENSYTLNGLK PNTAYDVKIR AHTSKGPGPY SPTVQYRTFQ
LDQAVLPKNF KVKLVTKTSV LLSWEFPENY NSPVTYKIQY NEDSIKVEGH TTKKLITNLK
PRTFYNFVLT NQGNSMGGLQ QNVAAWTASD ILTKKPEVTH RADIDGSVVV ILPDVKTTVP
VQAYYIVVVP LKKSRGNPMS SPEEMDLEEL VQNISRVQRR SLRHSRHLEV AKPYIAARFR
VLPSHFLLGD MKHYDNFENK ALEAGQRYVV FILAVLQDYE ATFAASPFSD VIQLDNPDPQ
PIIDGEEGLI WVIGPVLAVV FIICIVIAIL LYKNKPDSKR KDSEPRTKCL LNNAEITPHH
PKDPVEMRRI NFQTPDSGLS SPLSDPEFDF ESMLSHPPIP IAELAEHTEH LKANDNLKLS
QEYESIDPGQ QFTWEHSNLE VNKPKNRYAN VIAYDHSRVI LLPIEGIVGS DYINANYIDG
YRKQNAYIAT QGPLPETFGD FWRMVWEQRS ATIVMMTKLE EKSRIKCDQY WPGRGTDTYG
MIQVTLLDTI ELATFCVRTF SLHKNGSSEK REVRQFQFTA WPDHGVPEYP TPFLAFLRRV
KTCNPPDAGP IVVHCSAGVG RTGCFIVIDA MLERIKHEKT VDIYGHVTLM RSQRNYMVQT
EDQYSFIHDA LLEAVACGNT EVPARNLYTY IQKLAQIEVG EHVTGMELEF KRLANSKAHT
SRFISANLPC NKFKNRLVNI MPYETTRVCL QPIRGVEGSD YINASFIDGY RQQKAYIATQ
GPLAETTEDF WRMLWENNST IVVMLTKLRE MGREKCHQYW PAERSARYQY FVVDPMAEYN
MPQYILREFK VTDARDGQSR TVRQFQFTDW PEQGVPKSGE GFIDFIGQVH KTKEQFGQDG
PISVHCSAGV GRTGVFITLS IVLERMRYEG VVDIFQTVKM LRTQRPAMVQ TEDEYQFCYQ
AALEYLGSFD HYAT
//
