ID A0A3Q0FZ49_ALLSI Unreviewed; 444 AA.
AC A0A3Q0FZ49;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Cytohesin-2 {ECO:0000256|ARBA:ARBA00040245};
DE AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042728};
GN Name=CYTH2 {ECO:0000313|RefSeq:XP_025052649.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025052649.1};
RN [1] {ECO:0000313|RefSeq:XP_025052649.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR RefSeq; XP_025052649.1; XM_025196864.1.
DR AlphaFoldDB; A0A3Q0FZ49; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF343; CYTOHESIN-2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 98..285
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 303..420
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 34..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 63..97
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 444 AA; 51222 MW; 82795F4A95B2F5B2 CRC64;
MGMALDRRGL VSQVFIQSQE APWTVLQCLP QDSSLGAPYP GQPQPTPSSA VPPDLTPEER
LELENIRRRK QELLVEIQRL RDELSEAMNE VEGLEANEGS KTLQRNRKMG MGRKKFNMDP
KKGIQFLVEN ELLRNTPEDI ARFLYKGEGL NKTAIGDYLG EREEFNIAVL HAFVDLHEFT
DLNLVQALRQ FLWSFRLPGE AQKIDRMMEA FAQRYCLCNP GVFQSTDTCY VLSFAVIMLN
TSLHNPNVRD KPTVERFITM NRGINDGGDL PEELLRNLYD SIRNEPFKIP EDDGNDLTHT
FFNPDREGWL LKLGGGRVKT WKRRWFILTD NCLYYFEYTT DKEPRGIIPL ENLSIREVED
PRKPNCFELY IPNNKGQLIK ACKTEADGRV VEGNHMVYRI SAPTQEEKDE WIKSIKAAVS
VDPFYEMLAA RKKRISVKKK QEQA
//
