ID A0A3Q0FZW5_ALLSI Unreviewed; 1044 AA.
AC A0A3Q0FZW5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Lysine-specific demethylase PHF2 isoform X6 {ECO:0000313|RefSeq:XP_025052909.1};
GN Name=PHF2 {ECO:0000313|RefSeq:XP_025052909.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025052909.1};
RN [1] {ECO:0000313|RefSeq:XP_025052909.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025052909.1; XM_025197124.1.
DR AlphaFoldDB; A0A3Q0FZW5; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd15554; PHD_PHF2_like; 1.
DR Gene3D; 1.20.58.1360; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041070; JHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23123:SF14; LYSINE-SPECIFIC DEMETHYLASE PHF2; 1.
DR PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR Pfam; PF17811; JHD; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 5..56
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 197..353
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 462..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..513
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 116395 MW; FEAB75D8E9EF3CA9 CRC64;
MATVPVYCIC RLPYDVTRFM IECDACKDWF HGSCVGVEED EAPDIDIYHC PNCEKTHGKS
TLKKKRNWHK HDTGQTTEVK PVQNGSQVFI KELRSRTFPS AEDIVVKVTG SQLTTEYLEE
NGFTEPILVP KKDGLGLAVP APTFYVSDVE NYVGPERSVD VTDVTKQKDC KMKLKEFVDY
YYSTNRKRVL NVTNLEFSDT RMSSFVEPPD IVKKLSWVEN YWPDDALLGK PKVTKYCLIC
VKDSYTDFHI DSGGASAWYH VLKGEKIFYL IKPASANISL YERWQSAANH SEMFFADQVD
KCYKCTVKQG QTLFIPSGWI YATLTPVDCL AFAGHFLHSL SVEMQMRAYE VERRLKIVSL
TQFPNYETAC WYMGKHLLET FKGLHKAGQQ PPPHLLQGAK ILNGAFRSWT KKQALVDHED
ELPENFKPAQ LIKDLAKEIR LSENASKANK TEASANVNVE EVCPVEKEET PSPIQVATPP
PPTEKVPKKK TPKNVKTPKP PKVPKPPKHP KPPKTPKVKG EGKKKGKKAK ESPPPAIPNL
DLLEAHTKEA LTKIETPKKG KNSKPDSLLK MEEEHKLEKT PLSGNKDNKF TFSFANKKLL
GSKGVKTQLN TTVFGSLQNF KEDKTKPVRD EYEYVSDDGE LKIDEFPIRR KKNTTKRDLP
FLSDKKETLQ HTPIKKPKVE SVSYKSDDSS DEDSLHIDTE AKPGRNSKVK KESGSSAGIL
DLLQASKEVG GLEYNTNSQP PASPSTQEAI QGMLSMANLQ SSDSCLQTSW NTNQAKNNSI
STQNSKKTGS SNNKNAGKRL LKKSTKNSID IEDYDDQDHL DACFKDSDYV YPSLESDEDN
PVFKSRSKKR KSSDDAPYSP TARVGPSVPR QDRPVREGTR VASIETGLAA AAAKLSQQEE
QKGKKKKNTK KKLSPNNTNK LSQEGSSPEP KLESHSSTLT DHEYTAGAST FGVAQVNRGS
QPMAPGVFLT QKRPSSSPNN AAAKGPCVNH HSTKEARMTA FSTPPLEAVP LCSQSGKRTK
KGMATAKQRL GKILKIHRNG KLLL
//
