ID A0A3Q0G078_ALLSI Unreviewed; 762 AA.
AC A0A3Q0G078;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 3 isoform X3 {ECO:0000313|RefSeq:XP_025052912.1};
GN Name=FGD3 {ECO:0000313|RefSeq:XP_025052912.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025052912.1};
RN [1] {ECO:0000313|RefSeq:XP_025052912.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_006018057.1; XM_006017995.2.
DR RefSeq; XP_025052912.1; XM_025197127.1.
DR AlphaFoldDB; A0A3Q0G078; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15740; FYVE_FGD3; 1.
DR CDD; cd13387; PH1_FGD3; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF14; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 189..373
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 402..501
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 562..620
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 650..749
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 85124 MW; 51A20519DD3B7483 CRC64;
MEPGLDSPKQ PSSNDSDMVA SSGCSASEKS EPDENEPDLI CSSDLSNTDI MKIKELSIGD
NKSHEDCTAV NVSKEPSGEL GNKDSTTELN GNGKIPNRDS GIDSPSCSVA GETFPNEEGT
EQKKSTASGN PIEMDTDKKG SKCSPVEQKR DSTQDEDSDM DDGSSEEQET AEVPKLEYLD
VNKCTEPQKL FNIANELLHT EEAYVRRLHL LDQVFCTQLS EAGIQSDVIT GIFSNISSIY
CFHGQFLLPE LKTRITEEWN INPRLGDIFQ KLAPFLKMYG EYVKNFDRAL DLVNTWMQRS
SSFKDVVQNV QKQEVCGNLT LQHHMLEPVQ RIPRYELLLK DYLKKLPEES PDRKDAEKSL
ELISTAANHS NAAIRKMEKM NKLLEVYERL GGEEDIVNPA NELIKEGHIQ KLSAKNGTAQ
DRYLFLFNSM VLYCVPKLRL IGQKFSVREK MDIAGLQVQE IVKQNASHTF SITGKKRSLE
LQARTEDEKR EWIQVIQATI EKHKQNSETF RAFNSSFSQE DEHFPDSSIA STSSVESMPG
ADGCSAFGGA DPCRKSSKSK RDKEKQACKS CNESFNSITK RRHHCKQCGA VICAKCSEFK
PLADNSRHNR VCKDCFQILS AAPSSPGAEA VGEQKKKIAT EKQSILAAEN SLFSSYLQFL
DKGKTWSKVL VTIPKTEPLV LYLQGVSQDG RSLRAIPLPG YEVSLPSSGE KFEAKHILKL
YQSQQTLYFS AEDEELQMKW MEILTKAAKG ETEDLTEGIS NP
//
