ID A0A3Q0G1G0_ALLSI Unreviewed; 1109 AA.
AC A0A3Q0G1G0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Protein patched homolog 1 isoform X3 {ECO:0000313|RefSeq:XP_025053484.1};
GN Name=PTCH1 {ECO:0000313|RefSeq:XP_025053484.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025053484.1};
RN [1] {ECO:0000313|RefSeq:XP_025053484.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR RefSeq; XP_025053484.1; XM_025197699.1.
DR AlphaFoldDB; A0A3Q0G1G0; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..264
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 852..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..989
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1109 AA; 123518 MW; C6DF7123C73CED70 CRC64;
MHWQEELIIG GTVKNSSGKL VSAQALQTMF QLMTPKQMYE HFKGYEYVSH INWNEDKAAA
ILEAWQRMYV EVVHQSVAQN STQKVLSFTT TTLDDILKSF SDVSVIRVAS GYLLMLAYAC
LTMLRWDCAK SQGAVGLAGV LLVALSVAAG LGLCSLIGIS FNAATTQVLP FLALGVGVDD
VFLLAHAFSE TGQNKRIPFE DRTGECLKRT GASVALTSIS NVTAFFMAAL IPIPALRAFS
LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF TSPCASRVIQ MEPQAYADNN
DNARYSPPPP YSRHSFAQET QITMQSTVQL RTEYDPHTQV YYTTAEPRSE ISVQPVTVTQ
DNLSCQSPES TSSTRDLLSQ FSESNMHCLE PPCTKWTLSS FAEKHYAPFL LKPKAKIVVI
FLFLGLLGLS LYGTTRVKDG LDLTDIVPRE TREYDFIAAQ FKYFSFYNMY IVTQKADYPN
TQHLLYELHK SFSNVTYVLL EENKQLPKMW LHYFRDWLQG LQDAFDSDWE TGKITYNNYK
NGSDDAVLAY KLLVQTGNRD KPIDVSQLTK QRLVDAGGII NPNAFYIYLT AWVSNDPVAY
AASQANIRPH RPEWVHDKAD YMPETRLRIP AAEPIEYAQF PFYLNGLRET SDFVEAIEKV
RAICNNYTSL GISSYPNGYP FLFWEQYIGL RHWLLLSISV VLACTFLVCA LFLLNPWTAG
IIVVVLALMT VELFGMMGLI GIKLSAVPVV ILIASVGIGV EFTVHVALAF LTAIGDKNRR
AVLALEHMFA PVLDGAVSTL LGVLMLAGSE FDFIVRYFFA VLAILTILGV LNGLVLLPVL
LSLFGPYPEV SPTNGRNRLS TPSPEPPPSI VRFALPPGQN NGSDSSDSEY SSQTTMSGLS
EELHQYEPTQ GSGAPIHQVR VEATENPVFA RSTVVQPENK HHQSNPRLQT NPEAGSQQTW
HQNRQAKRES MEGLRPPPYR PRRDAFEIST EGHSGPNNKD RLGHRARSHN IRNPAFTAMG
ASVPAYCQPI TTVTASASVT VAVHPAVHSH NSRGGGFPSY EGYQETDHGP FEDPHVPFNV
RCERRNSKVE VIELQDVECE ERTHGNGSD
//
