ID A0A3Q0G1L2_ALLSI Unreviewed; 1984 AA.
AC A0A3Q0G1L2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRS {ECO:0000313|RefSeq:XP_025052265.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025052265.1};
RN [1] {ECO:0000313|RefSeq:XP_025052265.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR RefSeq; XP_025052265.1; XM_025196480.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14627; R-PTP-S-2; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_025052265.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 63..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1319..1342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..182
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 194..292
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 300..382
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 389..479
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 484..578
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 582..671
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 676..773
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 778..877
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 878..975
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 976..1072
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1076..1167
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1429..1684
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1604..1675
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1716..1975
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1893..1966
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 20..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1984 AA; 221904 MW; 5396A7262E5EEFC8 CRC64;
MEVATWPRSC TLFELSKDSL PNSAPASARP GGEGADVASE TPRALLTWSL SGGGRRSLPR
MRILSGPGMP SFIPLVTLLS LLLIACVAES PPVFIKKPVD QIGVSGGVAS FVCQATGDPK
PRVTWNKKGK KVNSQRFETI EFDESAGAVL RIQPLRTPRD ENIYECVAQN LHGEVTVQAR
LTVLREDQLP PGFPNIDMGP QLKVVERTRT ATMLCAASGN PDPEITWFKD FLPVDPSASN
GRIKQLRSET FEGTPIRGGL QIESSEETDQ GKYECVASNS AGVRYSSPAN LYVRVRRVAP
RFSILPVSHE IMPGGNVNIT CVAVGSPMPY VKWMQGAEDL TPEDDMPVGR NVLELTDVKD
SANYTCVAMS SLGVIEAVAQ ITVKSLPKAP GTPMVTETTA TSITITWDSG NPDPVSYYVI
EYKSKSQDGP YQIKEDITTT RYSIGGLSPN SEYEIWVSAV NSIGQGPPSE SVVTRTGEQA
PASAPRNVQG RMLSSNTMII QWEEPVEPNG QIRGYRVYYT MEPDQPVSNW QKHNMDDSLL
TTVGSLLEDE TYTVRVLAFT SVGDGPLSDP IQVKTQQGVP GQPMNFRAEA KTETSILLSW
SPPRQEIIVK YDLLFREGDH SREVSRTFDP ATSFMVENLK PNTEYVFRLA ARSDLGLGAF
TPEVRERTLQ SKPSAPPQDV KCVSTRSTAI LVSWRPPPAE SQNGVLVGYS IRYRALDSED
TELKEVNDIP PTTNQILLES LEKWTEYRIA VVAHTEVGPG PESSPVIVRT DEDVPSAPPR
KVEVEVLNST AIQVFWRSPV QNRQHGQIRG YQVHYVRMEN GEAKGLPQIK DVMLADAQDM
IIAGLQPETA YSITVAAYTM KGDGARSKPK LAMTKGAVPG KPILSVHQTQ ENALLVKWEP
PLEAEGQVMG YRLQFGRQDI APLATLEFAA QEDKYTAVNI HKGATYVFKL AVKSRAGFGE
EAVQELTIPE DIPKGYPQIL EASNISSMSV QFGWLPPVLA ERNGAIVKYT VAYWEAGSPS
NLLEKDLPPS PENSYTLNGL KPNTAYDVKI RAHTSKGPGP YSPTVQYRTF QLDQVLPKNF
KVKLVTKTSV LLSWEFPENY NSPVTYKIQY NEDSIKVEGH TTKKLITNLK PRTFYNFVLT
NQGNSMGGLQ QNVAAWTASD ILTKKPEVTH RADIDGSVVV ILPDVKTTVP VQAYYIVVVP
LKKSRGNPMS SPEEMDLEEL VQNISRVQRR SLRHSRHLEV AKPYIAARFR VLPSHFLLGD
MKHYDNFENK ALEAGQRYVV FILAVLQDYE ATFAASPFSD VIQLDNPDPQ PIIDGEEGLI
WVIGPVLAVV FIICIVIAIL LYKNKPDSKR KDSEPRTKCL LNNAEITPHH PKDPVEMRRI
NFQTPDSGLS SPLSDPEFDF ESMLSHPPIP IAELAEHTEH LKANDNLKLS QEYESIDPGQ
QFTWEHSNLE VNKPKNRYAN VIAYDHSRVI LLPIEGIVGS DYINANYIDG YRKQNAYIAT
QGPLPETFGD FWRMVWEQRS ATIVMMTKLE EKSRIKCDQY WPGRGTDTYG MIQVTLLDTI
ELATFCVRTF SLHKNGSSEK REVRQFQFTA WPDHGVPEYP TPFLAFLRRV KTCNPPDAGP
IVVHCSAGVG RTGCFIVIDA MLERIKHEKT VDIYGHVTLM RSQRNYMVQT EDQYSFIHDA
LLEAVACGNT EVPARNLYTY IQKLAQIEVG EHVTGMELEF KRLANSKAHT SRFISANLPC
NKFKNRLVNI MPYETTRVCL QPIRGVEGSD YINASFIDGY RQQKAYIATQ GPLAETTEDF
WRMLWENNST IVVMLTKLRE MGREKCHQYW PAERSARYQY FVVDPMAEYN MPQYILREFK
VTDARDGQSR TVRQFQFTDW PEQGVPKSGE GFIDFIGQVH KTKEQFGQDG PISVHCSAGV
GRTGVFITLS IVLERMRYEG VVDIFQTVKM LRTQRPAMVQ TEDEYQFCYQ AALEYLGSFD
HYAT
//