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Database: UniProt
Entry: A0A3Q0G1L2_ALLSI
LinkDB: A0A3Q0G1L2_ALLSI
Original site: A0A3Q0G1L2_ALLSI 
ID   A0A3Q0G1L2_ALLSI        Unreviewed;      1984 AA.
AC   A0A3Q0G1L2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN   Name=PTPRS {ECO:0000313|RefSeq:XP_025052265.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025052265.1};
RN   [1] {ECO:0000313|RefSeq:XP_025052265.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001490};
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR   RefSeq; XP_025052265.1; XM_025196480.1.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd00063; FN3; 8.
DR   CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR   CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR   CDD; cd14627; R-PTP-S-2; 1.
DR   CDD; cd14625; R-PTPc-S-1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR   Pfam; PF00041; fn3; 7.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13927; Ig_3; 2.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00014; FNTYPEIII.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 8.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 5.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50853; FN3; 8.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Receptor {ECO:0000313|RefSeq:XP_025052265.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1319..1342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          92..182
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          194..292
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          300..382
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          389..479
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          484..578
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          582..671
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          676..773
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          778..877
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          878..975
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          976..1072
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1076..1167
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1429..1684
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1604..1675
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   DOMAIN          1716..1975
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1893..1966
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          20..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1347..1375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1984 AA;  221904 MW;  5396A7262E5EEFC8 CRC64;
     MEVATWPRSC TLFELSKDSL PNSAPASARP GGEGADVASE TPRALLTWSL SGGGRRSLPR
     MRILSGPGMP SFIPLVTLLS LLLIACVAES PPVFIKKPVD QIGVSGGVAS FVCQATGDPK
     PRVTWNKKGK KVNSQRFETI EFDESAGAVL RIQPLRTPRD ENIYECVAQN LHGEVTVQAR
     LTVLREDQLP PGFPNIDMGP QLKVVERTRT ATMLCAASGN PDPEITWFKD FLPVDPSASN
     GRIKQLRSET FEGTPIRGGL QIESSEETDQ GKYECVASNS AGVRYSSPAN LYVRVRRVAP
     RFSILPVSHE IMPGGNVNIT CVAVGSPMPY VKWMQGAEDL TPEDDMPVGR NVLELTDVKD
     SANYTCVAMS SLGVIEAVAQ ITVKSLPKAP GTPMVTETTA TSITITWDSG NPDPVSYYVI
     EYKSKSQDGP YQIKEDITTT RYSIGGLSPN SEYEIWVSAV NSIGQGPPSE SVVTRTGEQA
     PASAPRNVQG RMLSSNTMII QWEEPVEPNG QIRGYRVYYT MEPDQPVSNW QKHNMDDSLL
     TTVGSLLEDE TYTVRVLAFT SVGDGPLSDP IQVKTQQGVP GQPMNFRAEA KTETSILLSW
     SPPRQEIIVK YDLLFREGDH SREVSRTFDP ATSFMVENLK PNTEYVFRLA ARSDLGLGAF
     TPEVRERTLQ SKPSAPPQDV KCVSTRSTAI LVSWRPPPAE SQNGVLVGYS IRYRALDSED
     TELKEVNDIP PTTNQILLES LEKWTEYRIA VVAHTEVGPG PESSPVIVRT DEDVPSAPPR
     KVEVEVLNST AIQVFWRSPV QNRQHGQIRG YQVHYVRMEN GEAKGLPQIK DVMLADAQDM
     IIAGLQPETA YSITVAAYTM KGDGARSKPK LAMTKGAVPG KPILSVHQTQ ENALLVKWEP
     PLEAEGQVMG YRLQFGRQDI APLATLEFAA QEDKYTAVNI HKGATYVFKL AVKSRAGFGE
     EAVQELTIPE DIPKGYPQIL EASNISSMSV QFGWLPPVLA ERNGAIVKYT VAYWEAGSPS
     NLLEKDLPPS PENSYTLNGL KPNTAYDVKI RAHTSKGPGP YSPTVQYRTF QLDQVLPKNF
     KVKLVTKTSV LLSWEFPENY NSPVTYKIQY NEDSIKVEGH TTKKLITNLK PRTFYNFVLT
     NQGNSMGGLQ QNVAAWTASD ILTKKPEVTH RADIDGSVVV ILPDVKTTVP VQAYYIVVVP
     LKKSRGNPMS SPEEMDLEEL VQNISRVQRR SLRHSRHLEV AKPYIAARFR VLPSHFLLGD
     MKHYDNFENK ALEAGQRYVV FILAVLQDYE ATFAASPFSD VIQLDNPDPQ PIIDGEEGLI
     WVIGPVLAVV FIICIVIAIL LYKNKPDSKR KDSEPRTKCL LNNAEITPHH PKDPVEMRRI
     NFQTPDSGLS SPLSDPEFDF ESMLSHPPIP IAELAEHTEH LKANDNLKLS QEYESIDPGQ
     QFTWEHSNLE VNKPKNRYAN VIAYDHSRVI LLPIEGIVGS DYINANYIDG YRKQNAYIAT
     QGPLPETFGD FWRMVWEQRS ATIVMMTKLE EKSRIKCDQY WPGRGTDTYG MIQVTLLDTI
     ELATFCVRTF SLHKNGSSEK REVRQFQFTA WPDHGVPEYP TPFLAFLRRV KTCNPPDAGP
     IVVHCSAGVG RTGCFIVIDA MLERIKHEKT VDIYGHVTLM RSQRNYMVQT EDQYSFIHDA
     LLEAVACGNT EVPARNLYTY IQKLAQIEVG EHVTGMELEF KRLANSKAHT SRFISANLPC
     NKFKNRLVNI MPYETTRVCL QPIRGVEGSD YINASFIDGY RQQKAYIATQ GPLAETTEDF
     WRMLWENNST IVVMLTKLRE MGREKCHQYW PAERSARYQY FVVDPMAEYN MPQYILREFK
     VTDARDGQSR TVRQFQFTDW PEQGVPKSGE GFIDFIGQVH KTKEQFGQDG PISVHCSAGV
     GRTGVFITLS IVLERMRYEG VVDIFQTVKM LRTQRPAMVQ TEDEYQFCYQ AALEYLGSFD
     HYAT
//
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