ID A0A3Q0G267_ALLSI Unreviewed; 582 AA.
AC A0A3Q0G267;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Small conductance calcium-activated potassium channel protein 1 isoform X2 {ECO:0000313|RefSeq:XP_025052168.1};
GN Name=KCNN1 {ECO:0000313|RefSeq:XP_025052168.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025052168.1};
RN [1] {ECO:0000313|RefSeq:XP_025052168.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_025052168.1; XM_025196383.1.
DR AlphaFoldDB; A0A3Q0G267; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR10153:SF38; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 1; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR PRINTS; PR01451; SKCHANNEL.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000313|RefSeq:XP_025052168.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..485
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
FT REGION 75..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 483..517
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 549..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 64979 MW; A15642E1D3B2C112 CRC64;
MVHAGSWALN HAGSVGAVSE PNPFTEIAMN SCKYNGGVVR PLGSLSASPR HLPELEAETQ
PLQTLHSAGL EAVVSKPEQA KVSDTSVDAG EEDEDDEEAA GAERARRQRK NQNVGYRLGH
RRALFEKRKR LSDYALIFGM FGIVVMVTET ELSWGIYTKE SSYSFALKCL ISLSTIILLG
LIIMYHAREI QLFMVDNGAD DWRIAMTYER IFFITLELLV CAIHPVPGQY IFTWTARLAF
TYTTSVADAD VDIILSIPMF LRLYLIGRVM LLHSKLFTDA SSRSIGALNK INFNTRFVMK
TLMTICPGTV LLVFSISSWI IAAWTVRVCE RYHDKQEVTS NFLGAMWLIS ITFLSIGYGD
MVPHTYCGKG VCLLTGIMGA GCTALVVAVV ARKLELTKAE KHVHNFMMDT QLTKRVKNAA
ANVLRETWLI YKHTKLVKKI DHAKVRKHQR KFLQAIHQLR SVKMEQRKLN DQANTLVDLA
KTQNVMYDLV SELQERNEDL EKRISTLEGK IDALGLSIHA LPGLITQAIT QQQQQQRRGQ
GPGTGTAARF CPGSNSSERS SWTPTRRRKS PSTAPHTSSD SG
//
