ID A0A3Q0G3D6_ALLSI Unreviewed; 506 AA.
AC A0A3Q0G3D6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Iroquois-class homeodomain protein IRX-6 isoform X2 {ECO:0000313|RefSeq:XP_025054184.1};
GN Name=IRX6 {ECO:0000313|RefSeq:XP_025054184.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025054184.1};
RN [1] {ECO:0000313|RefSeq:XP_025054184.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR RefSeq; XP_025054184.1; XM_025198399.1.
DR AlphaFoldDB; A0A3Q0G3D6; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR PANTHER; PTHR11211:SF11; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-6; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 145..208
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 147..209
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 209..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 55613 MW; 20D77F8B889842ED CRC64;
MSFSQFGYPY STTSQFFVSA SPSTTCCESA SRSVSDVTSG SAQAATLCCP SYENRLLAST
RTELNAALGM YSSPYAAAAA SQSYANYLPY SADPSTLYTT LNPQYEIKDG TSSLHSGIAQ
PAAYYPYDHS LGQYQYDSRY GTVDFSGSAR RKNATRETTS TLKTWLYEHR KNPYPTKGEK
IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWSPKNKAG EERKEENKRE EEEYDLEPEG
KADQKSCKEE KELRLSDLDD LDEEEAEKLD GDRKGTHQEA SSLSTALAES EKSDCSLTPP
SSFHTFPCSK TSSAAAGDFL ETVGQKPGPL VGTMSQVQQY ETTEKPRIWS LAHTAGANVI
IGPSTPEPRT VSPDCLLLRG RHAVPGHCSE GRPLASLRTQ PGTDSAFEEL PQPTKIFRNS
TFNLQSIQLN CASYPVLGET CQYSSGAEGF GRNVKPTQGA IDLSEACLVQ HKDKLRTAFR
PVLKSRLACL FENPEDGSQS ASRLLA
//
