ID A0A3Q0G5B8_ALLSI Unreviewed; 1903 AA.
AC A0A3Q0G5B8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|RefSeq:XP_025053308.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025053308.1};
RN [1] {ECO:0000313|RefSeq:XP_025053308.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025053308.1; XM_025197523.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14628; R-PTP-D-2; 1.
DR CDD; cd14624; R-PTPc-D-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045905; R-PTP-delta_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_025053308.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1903
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018248961"
FT TRANSMEM 1258..1281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..122
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 134..223
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 235..317
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 324..414
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 419..515
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 517..606
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 611..708
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 713..812
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 813..906
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 911..1006
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1011..1097
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1348..1603
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1523..1594
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1635..1894
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1812..1885
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 400..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1903 AA; 213603 MW; B2084960667004B7 CRC64;
MLVPSCRMMH VARPVVVLLC FLLYADAETP PKFTRTPVDQ TGVSGGVASF ICQATGDPRP
KIVWNKKGKK VSNQRFEVVI EFDDGSGSVL RIQPLRTPRD EAIYECVASN SVGEISVSTR
LTVLREDQIP RGFPTIDMGP QLKVVERTRT ATMLCAASGN PDPEITWFKD FLPVDTSNNN
GRIKQLRSGA LQIELSEESD QGKYECVATN SAGTRYSAPA NLYVRELREV RRVPPRFSIP
PTNHEIMPGG SVNITCVAVG SPMPYVKWML GAEDLTPEDD MPIGRNVLEL NDVRQSANYT
CVAMSTLGVI EAIAQITVKA LPKPPGTPVV TESTATSITL TWDSGNPEPV SYYIIQHKPK
NSEEPYKEID GVATTRYSVA GLSPYSEYEF RVVAVNNIGR GPPSEPVSTR TSEQAPSSAP
RNVQARMLSS TTILVQWEEP EEPNGQIQGY RVYYTMDPTQ HVNSWMKHNV ADSHITTIGN
LVPQKTYSVK VLAFTSVGDG PLSSEIQVIT QTGVPGQPLN FKAEPESETS ILLSWTPPRS
DTIANYELVY KDGEHAEEQR VSIEPTTSYR LQGLRPNSLY YFRLAARSPQ GLGASTAEIS
ARTMQSKPSA PPQDISCMSP SSTSILVSWK PPPVEKQNGI ITEYSIKYIG IDGEDDKPHE
ILGISSDTTH YLLEQLEKWT EYRISVTAYT DVGPGPESLA VLIRTDEDVP SGPPRKVEVE
AVNSTAVKVS WRSPVPNKQH GQIRGYQVHF VRMENGEPKG QPMLKDVMLA DAQEMFISGL
QPETTYSLTV TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV ISHTQMNTAL IQWHPPVDTF
GPLQGFRLKF GRKDMDTFTT LEFSEKEDHF TATDIHKGAS YVFRLSAKNK VGFGEEMVKE
IYVPEEVPSG FPQNLHSESS TSTSVQLTWQ PPILAERNGV ITKYTLLYRD INVAHHPVEF
PIAPADTTMT LSGLKPDTTY DVKVRAHTSK GPGPYSPSVQ FRTLPVDQAV FAKNFHVKAV
MKTSVLLSWE IPENYNSAMP FKILYDDGKM VVEVDGRATQ KLIINLKPET SYSFVLTNRG
NSAGGLQHRV TAKTAPDVLR TKPVFIGKTN LDGMITVELP EVPANENIKG YYIVIVPLKK
SRGKFIKPWE SPDEMELDEL LKEIARKRRS IRFGREVELK PYIAAHFEVL PTEFTLGDKK
QYGGFENKQL QSGQEYVFFV LAVMEHSEST MYATSPYSDP VVSMDLDPQP ITDEEEGLIW
VVGPVLAVVF IICIVIAILL YKRKRAESDS RKSSIPNNKE IPSHHPTDPV ELRRLNFQTP
GMASHPPIPI LELADHIERL KANDNLKFSQ EYESIDPGQQ FTWEHSNLEV NKPKNRYANV
IAYDHSRVLL SAIEGIPGSD YINANYIDGY RKQNAYIATQ GSLPETFGDF WRMMWEQRGA
TVVMMTKLEE RSRVKCDQYW PSRGTETYGL IQVTLLDTVE LATYCVRTFA LYKNGSSEKR
EVRQFQFTAW PDHGVPEHPT PFLAFLRRVK TCNPPDAGPM VVHCSAGVGR TGCFIVIDAM
LERIKHEKTV DIYGHVTLMR AQRNYMVQTE DQYIFIHDAL LEAVTCGNTE VPARNLYAYI
QKLTQIETGE NVTGMELEFK RLASSKAHTS RFISANLPCN KFKNRLVNIM PYESTRVCLQ
PIRGVEGSDY INASFIDGYR QQKAYIATQG PLAETTEDFW RMLWEHNSTI VVMLTKLREM
GREKCHQYWP AERSARYQYF VVDPMAEYNM PQYILREFKV TDARDGQSRT VRQFQFTDWP
EQGVPKSGEG FIDFIGQVHK TKEQFGQDGP ISVHCSAGVG RTGVFITLSI VLERMRYEGV
VDIFQTVKML RTQRPAMVQT EDQYQFCYRA ALEYLGSFDH YAT
//