ID A0A3Q0G5I7_ALLSI Unreviewed; 978 AA.
AC A0A3Q0G5I7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_025053378.1};
GN Name=ASAP2 {ECO:0000313|RefSeq:XP_025053378.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025053378.1};
RN [1] {ECO:0000313|RefSeq:XP_025053378.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025053378.1; XM_025197593.1.
DR AlphaFoldDB; A0A3Q0G5I7; -.
DR STRING; 38654.A0A3Q0G5I7; -.
DR InParanoid; A0A3Q0G5I7; -.
DR OrthoDB; 1449795at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08849; ArfGap_ASAP2; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR CDD; cd11966; SH3_ASAP2; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR035677; ASAP2_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF4; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 255..347
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 371..493
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 570..602
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 916..978
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 230..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..847
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 108876 MW; C3ECF59312DD451F CRC64;
MKKSVKAINV SGLAHVENEE QYTQALEKFG GNCVCRDDPD LGTAFLKFSV FTKELTALFK
NLIQNMNNII TFPLDSLLKG DLKGVKGDLK KPFDKAWKDY ETKVTKIEKE KKEHAKLHGM
IRTEISGAEI AEEMEKERRF FQLQMCEYLL KVNEIKIKKG VDLLQNLIKY FHAQCNFFQD
GLKAVESLKP SIEMLSTDLH TIKQAQDEER KQLIQLRDIL KSALQVEQKE SRRDSQIRQS
TTYSLHQPQG NKEHGTERNG SLYKKSDGIR KVWQKRKCSV KNGFLTISHG TANRPPAKLN
LLTCQVKTNP EEKKCFDLIS HDRTYHFQAE DEQECQIWTS VLQNSKEEAL NNAFKGDDNT
GENNIVQELT KEIISEVQRM TGNDVCCDCG AQDPTWLSTN LGILTCIECS GIHRELGVHY
SRMQSLTLDV LGTSELLLAK NIGNAGFNEI MEFCLPVDET VKPNPSSDMN ARKDYITAKY
IERKYARKKH IDNAAKLHAL CEAVKTRDIF GLVQVYADGV DLTEKIPLAN GHEQDETALH
LAVRSVDRTS LHIVDFLVQN SGNLDKQTCK GSTALHYCCL TDNVECLKLL LRGKASIEIA
NESGETPPDI AKRLKHTHCE ELLTQALSGR FNSHVHVEYE WRLLHEDLDE SDDDVDEKLQ
QPSPNRREDR PVSFYQLGSN QLQPNVASLA RDAANIAKDK QRGFMPSILQ NETYGAILSG
SPPPIQPAVP VTTSAPPLPP RNIGKVQPSV LGSGVQTTSS NTMWKTNSLG VESISRQRSS
SDPPAIHPPV PPLRVTSTNM ISPAPPPPVA KTASVIEALN HQSKQVQAVP QAKPIPPPLP
PQPPNRISQK KPSSGADKSS PLTNKGQPRG PGTLQQSGES TCVSEAPVPQ TGSAANTLTQ
IQPPAPMPRK SQLSKTKPKR VKAIYNCVAD NPDELTFSEG DIIVVDGEED HEWWIGHIDG
DPNRKGAFPV SFVHFIVD
//
