ID A0A3Q0G601_ALLSI Unreviewed; 935 AA.
AC A0A3Q0G601;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Transcription factor E2F8 {ECO:0000256|ARBA:ARBA00039673};
GN Name=E2F8 {ECO:0000313|RefSeq:XP_025055104.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025055104.1};
RN [1] {ECO:0000313|RefSeq:XP_025055104.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025055104.1; XM_025199319.1.
DR AlphaFoldDB; A0A3Q0G601; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF40; TRANSCRIPTION FACTOR E2F8; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 117..186
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 263..349
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 935 AA; 103651 MW; D2148D21CF2FA869 CRC64;
MEKEPTCKMQ ENCSSEPCKS TLKTPLKQSA TSHSVLAEIQ SNSGPLTTPP KPKEIPLGDP
WTPTTNLKIL ISAASPEIRN REQKKGLQDS RSEILEANHC LQEHLSGDEY EKSQPSRKEK
SLGLLCHKFL ARYPDYPITG ESNYICLDEV AEELTVERRR IYDIVNVLES LHMVSRLAKN
RYAWHGRHNL NKTLQTLKKV GEENKYMQLI QLIKKREYEN EFELDGEKNE ETATKTIGIN
EHSEMCFIEL PGMEFRAASV NSRKDKSLRV MSQKFVMLFL VSTPQIVSLE VAAKILIGED
HVEDLDKSKF KTKIRRLYDI ANVLSSLELI KKVHITEERG RKPAFKWTGP EVLSDIQGTK
PISTVSAFIP SHSLEPKPSK EQCSKNLFPA RGKQIFTRHP SLMKLVKSIE SDRRIHSAPT
SPVKTSTTGC DQNSSTFPSK MAQLAAICKQ QLEGQSSELK MKTKLTSNLE CNLAAPESIL
KSETYTTSPS PSLVHSLGVL PLSHNSMSPV MLPHPHAGVS YTIYLHPSQT QTATTYSPSF
VLQSVPCTNV TGVKTALEVN SKVPFSKMTT EEGDGNVVKN DTNFLNAKEK KVTKIESTPR
SFLKRSQALQ ENNLIKKCKH GQKSLGVPMG ESVKNERPSS RALHVDTEVV SFQERGQIKF
EKLDQNMECC CDKERREGFP EDRSKTSNTQ ERPVPFAVHA HEALFPSGYL IPIARCTQHS
NETMFSNKEK AGICSLQPAT YSSPITGVIP VTASELTAVN IPAFHVTPMN IMVSPSSIAA
APVVNSSCLN SGHTHSVQNP SSSILNFTLQ HLGLIPAGVQ VSGNPVLQSL PISPKAEHVN
TVSENVNLQQ GKVVKNESQI LDCELNGKSV AVIPLQQQPS VPAKPKESQV VTENFFRTPG
GPNTIASLSS FPENSDRAFQ RTLTIPQRKL EVSDD
//