ID A0A3Q0G6T2_ALLSI Unreviewed; 883 AA.
AC A0A3Q0G6T2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Circadian locomoter output cycles protein kaput {ECO:0000256|ARBA:ARBA00040572};
GN Name=CLOCK {ECO:0000313|RefSeq:XP_025054134.1,
GN ECO:0000313|RefSeq:XP_025054135.1, ECO:0000313|RefSeq:XP_025054136.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025054135.1};
RN [1] {ECO:0000313|RefSeq:XP_025054134.1, ECO:0000313|RefSeq:XP_025054135.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR RefSeq; XP_025054134.1; XM_025198349.1.
DR RefSeq; XP_025054135.1; XM_025198350.1.
DR RefSeq; XP_025054136.1; XM_025198351.1.
DR STRING; 38654.A0A3Q0G6T2; -.
DR KEGG; asn:102379511; -.
DR OrthoDB; 2899615at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd19734; bHLH-PAS_CLOCK; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF2; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 39..89
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 112..182
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 307..354
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 439..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 551..585
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 449..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 100154 MW; F5B2166847455F61 CRC64;
MFFTVSTHKM SSIADSFFSC RDDGSIFDGL VEEDDKDKAK RVSRNKSEKK RRDQFNVLIK
ELGSMLPGNA RKMDKSTVLQ KSIDFLRKHK EISAQSDASE IRQDWKPTFL SNEEFTQLML
EALDGFFLAI MTDGSIIYVS ESVTPLLEHL PSDLVDQSIF NFVPEGEHSE VYKILSNHLP
ESDSLTPEYL KSKNQLEFCC HMLRGTIDPK EQTTYEYVKF IGNFKCLNNK YEKLSRRGDY
QSCYIFLPNS AHNGYEGTIQ RSHRPSYEDK VCFVATVRLA TPQFIKEMCT VEEPNEEFTS
RHSLEWKFLF LDHRAPPIIG YLPFEVLGTS GYDYYHVDDL ENLAKCHEHL MQYGKGKSCY
YRFLTKGQQW IWLQTHYYIT YHQWNSRPEF IVCTHTVVSY AEVRAERRRE LGIEESLPEI
TADKSQDSGS DNRINTVSLK EALERFDRSP TPSASSRSSR KSSHTAVSDH SSTPTKMTMD
TSTPPRQNLS GHEKTTQRRS SLTSQSLSSQ SAGQPLAQPM MSQSASLQIQ PGMSQPMFQF
SAQLGAMQHL KDQLEQRTRM IEANIHRQQE ELRKIQEQLQ LVHGQGLQMF LQQSPPGLNF
GSVQLTSGNS SNLQQLTPIN MQSPVVQTNQ IQGGMNTGHI STQHMIQQQP LQNTVTQHNQ
PNVLSGHNQQ TSLSSQSQST LSAPLYNTMV ISQPTTGNVV QIPSSLPQNN NQSGAAVTTF
TQDRQIRFSQ GQQLVTKLVT APVACGAVMV PSTMFMGQVV TAYPTFAAQQ QQAQTLSITQ
QQQQQQQQGQ QQQQQQLSTV QQPAQTQLAH HPQQFLQTSR LLHGNQSAQL ILSAAFPLQQ
STFTQSHHPQ HQSQQQPPQQ QQQQQLSRLR TDTMTDPSKI QPQ
//
