ID A0A3Q0G7Z2_ALLSI Unreviewed; 745 AA.
AC A0A3Q0G7Z2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Cell surface glycoprotein MUC18 isoform X2 {ECO:0000313|RefSeq:XP_025055764.1};
GN Name=MCAM {ECO:0000313|RefSeq:XP_025055764.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025055764.1};
RN [1] {ECO:0000313|RefSeq:XP_025055764.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025055764.1; XM_025199979.1.
DR AlphaFoldDB; A0A3Q0G7Z2; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11973:SF18; CELL SURFACE GLYCOPROTEIN MUC18; 1.
DR PANTHER; PTHR11973; CELL SURFACE GLYCOPROTEIN MUC18-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 659..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..336
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 350..449
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 460..541
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 548..635
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 23..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 81460 MW; 1FE412F6EE2B776E CRC64;
MPGEQLVRPP PLLHLACTHL ASGGNLKPTA GTQAKDRGSE GAPRGGHRAQ HPTALEARSP
QARRGKAAWR CEHCRERRLL ICRELVGAAP SQTLEEIISG ARSLECAIVL HRRPAEQTCQ
RGHGNPGNPD TGYASKVEVS TPSVVEVDLG HTAMLPCSFF ILPDSNITYV YWSYIPRSSR
TKVYSWVQGK VFVDDSPYVG RVSMDDTFTL AITQTTLQDA RVFVCQVGAG SLGVGENRTE
LRVYKAPEPP EIHANEAGIS VGTRESQEIA ECVVRNSFPG PNITWLKDGH RLHPEDDKVK
IMDTRTQEAS GLFTARSRLL AHVPRQDRHA YFQCQAHYLL AGGDRQAQSP KVQVHIFYPT
ENVSLAIDAP RPQVKEGDHV ALRCQGDGNP PPEYSFFRVQ NNTATGEEEE QELSGKADKG
VLSLGKVHKE NTGHYRCKGL DLDTMETLTA DAELVVNYIE GLKVTKESPE PVLEGHNLTL
TCEARGSRPL AFHWHKDKKG KALGSGQQLQ LSNIMREAAG NYICEVTMPG VQGLSRNKQV
LVVVYGKPQV SVEKPGVPVQ ENELVTLTCT ALAQPEPSIT WSANGTVQNR TENYSVVSNL
TVQVTSKLMR SGINCTATNY LGVVTHHVHL ERRMTPTTPT TTAPAGNATE QKPQESKGVI
IVAVIVCILV LAVLGAVLYF LHKKGKIPCG RTGKQDITKP DARKDEVVVE VKSDKLPEEA
GLLQATNGDQ KPAGDQGEKY IDLRH
//
