ID A0A3Q0G8J0_ALLSI Unreviewed; 740 AA.
AC A0A3Q0G8J0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Cell surface glycoprotein MUC18 isoform X4 {ECO:0000313|RefSeq:XP_025055767.1};
GN Name=MCAM {ECO:0000313|RefSeq:XP_025055767.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025055767.1};
RN [1] {ECO:0000313|RefSeq:XP_025055767.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025055767.1; XM_025199982.1.
DR AlphaFoldDB; A0A3Q0G8J0; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11973:SF18; CELL SURFACE GLYCOPROTEIN MUC18; 1.
DR PANTHER; PTHR11973; CELL SURFACE GLYCOPROTEIN MUC18-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 653..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..330
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 344..443
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 454..535
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 542..629
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 713..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 81029 MW; 763454BDA0E87C94 CRC64;
MPRGTPTWRA ESLVLKGLPP QGPALLEQLG SSLQEQDAGG SHARSGTFLE PQQQVRLGSI
APCSRDPALP GALRICRTSR FRHYHIKEKE IISGARSLEC AIVLHRRPAE QTCQRGHGNP
GNPDTGYASK VEVSTPSVVE VDLGHTAMLP CSFFILPDSN ITYVYWSYIP RSSRTKVYSW
VQGKVFVDDS PYVGRVSMDD TFTLAITQTT LQDARVFVCQ VGAGSLGVGE NRTELRVYKA
PEPPEIHANE AGISVGTRES QEIAECVVRN SFPGPNITWL KDGHRLHPED DKVKIMDTRT
QEASGLFTAR SRLLAHVPRQ DRHAYFQCQA HYLLAGGDRQ AQSPKVQVHI FYPTENVSLA
IDAPRPQVKE GDHVALRCQG DGNPPPEYSF FRVQNNTATG EEEEQELSGK ADKGVLSLGK
VHKENTGHYR CKGLDLDTME TLTADAELVV NYIEGLKVTK ESPEPVLEGH NLTLTCEARG
SRPLAFHWHK DKKGKALGSG QQLQLSNIMR EAAGNYICEV TMPGVQGLSR NKQVLVVVYG
KPQVSVEKPG VPVQENELVT LTCTALAQPE PSITWSANGT VQNRTENYSV VSNLTVQVTS
KLMRSGINCT ATNYLGVVTH HVHLERRMTP TTPTTTAPAG NATAEQKPQE SKGVIIVAVI
VCILVLAVLG AVLYFLHKKG KIPCGRTGKQ DITKPDARKD EVVVEVKSDK LPEEAGLLQA
TNGDQKPAGD QGEKYIDLRH
//
