ID A0A3Q0G8Q8_ALLSI Unreviewed; 715 AA.
AC A0A3Q0G8Q8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=WWP1 {ECO:0000313|RefSeq:XP_025056019.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025056019.1};
RN [1] {ECO:0000313|RefSeq:XP_025056019.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025056019.1; XM_025200234.1.
DR AlphaFoldDB; A0A3Q0G8Q8; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd00201; WW; 4.
DR Gene3D; 2.20.70.10; -; 3.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR024928; E3_ub_ligase_SMURF1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF299; NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00397; WW; 4.
DR PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00456; WW; 4.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF51045; WW domain; 4.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 4.
DR PROSITE; PS50020; WW_DOMAIN_2; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 143..176
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 175..208
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 250..283
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 290..323
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 381..715
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 683
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001569-1,
FT ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 715 AA; 82371 MW; 7F0E55E7B1A62706 CRC64;
MHTVNGDSTS SPSHVARPKT TPKPLTTQPT NNTVNGESLS VPEADDSSAS EAFTGSVEAS
TSTDCTNTTP ETLSTTEATS YSENNMSTTI SIVSVGLETV TATDSASSTA RSSTATEAAK
PRESSSGASV ESVRQQPGNA STEPLPPGWE QRKDPHGRTY YVDHNTRTTT WERPQPLPPG
WERRVDDRGR VYYVDHNTRT TTWQRPTMES VRNFEQWQSQ RNQLQGAMQQ FNQRYLYSAS
MLTAENDPLG PLPPGWERRV DSNDRVYFVN HNTKTTQWED PRTQGLQNED PLPEGWEIRY
TREGVRYFVD HNTRTTTFSD PRTGKSSVNK GPQIAYERSF RWKLAHFRYL CQSNALPSHV
KINVSRQTLF EDSFQQIMAL KPYDLRRRLY VIFRGEEGLD YGGLAREWFF LLSHEVLNPM
YCLFEYAGKS NYCLQINPAS TINPDHLSYF CFIGRFIAMA LFHGKFIDTG FSLPFYKRML
NKKLTIKDLE SIDTEFYNSL IWIRDNNIEE CNLEMYFCVD MELLGKVTSH ELKSGGSNIL
VTEENKEEYI GLMAEWRFSR GVRDQTKAFL DGFNEVVPLQ WLQYFDEKEL EVMLCGMQEV
DLADWQRNTV YRHYTRNSKQ IIWFWQFVKE TDNEVRMRLL QFVTGTCRLP LGGFAELMGS
NGPQKFCIEK VGKETWLPRS HTCFNRLDLP PYKSYEQLKE KLLFAIEETE GFGQE
//