ID A0A3Q0GA44_ALLSI Unreviewed; 1007 AA.
AC A0A3Q0GA44;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=SMARCAD1 {ECO:0000313|RefSeq:XP_025055295.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025055295.1};
RN [1] {ECO:0000313|RefSeq:XP_025055295.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR RefSeq; XP_025055295.1; XM_025199510.1.
DR AlphaFoldDB; A0A3Q0GA44; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd14279; CUE; 1.
DR CDD; cd17998; DEXHc_SMARCAD1; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR PANTHER; PTHR10799:SF964; SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD_H BOX 1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 2.
DR SMART; SM00546; CUE; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51140; CUE; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 162..204
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT DOMAIN 250..293
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT DOMAIN 511..659
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 840..1001
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 114435 MW; 9644C02A87FB8781 CRC64;
MSQFNLDRFR FEKRSQVGEQ ENLPSPLPAA RPPAASDAAA SNGGGGEEDN EVTDDSSRPD
TPASDVTEKT EDSSVSETPE VEKTTKLSHF KNRRNLQYID VSSDSEDQES QNCSTTKHDN
VLQRDVIVIS EQSDDEQPQD EVPNLTYANG TDQSQNMEEE DIIDAKLQTL KELFPQRNDQ
ELLQLIKSTH TMDEAIAAAL THSDEAASRK RKLEQSPREN SDDDDDDDQI AKKQKADSQE
GSASQKEWEK QETLVKKLQN EFPGLDKKEL RDVLQEHNWV FHEALEALKV FAEDQEDAQN
PSISEVSNWN EVSTNSKNDQ NSAKVKMKQK SSTKTQNGFR KKDKGKKGIW STKREMEDSE
YESASEGGSS LDEDYSSGDE VMEDGCTTKI LNFLQDASLG ELTWIPQCSQ KKAQKIIELR
PFNSWEALVS KMSKTNGLSE DIIWNCKTLL RERDVVLKLM NKCEDISNKL TNQVTRITED
GGCGWNIEQP SILNQSLELK PYQKIGLNWL ALLHQHGLNG ILADEMGLGK TIQAIAFLAY
LYQQGNKGPH LIVVPASTLG SQEDRKHLRI DINNKAVDFN VIVTTYNCAI SSSDDRSLFR
RLKLNYAIFD EGHMLKNMGS VRYQHLMTIN AMNRLLLTGT PVQNNLLELM SLLNFVMPHM
FSSSTSEIRR MFSSKTKTAE EQSIYEKERI AHAKQIIKPF ILRRVKDEVL KQLPPKRDLI
ELCAMSEKQE QLYYDLLNKI KKSIDSEEKN SDTGNVMMQL RKMANHPLLH RQYYTDDKLR
IMSTLMLKEP THCDANPDLI FEDMTVMTDF ELHLLCKQYA NVSDFKLEMD QILDSGKFRT
LEHILSDLKE KGDRVVLFSQ FTMMLDILEV LLKQQQHRYI RLDGKTQISE RIHLIDEFNT
DMGIFVFLLS TKAGGLGINL TSANVVILHD IDCNPYNDKQ AEDRCHRVGQ TREVQVIKLI
SKGTIEESML KISQQKLKLE QDMTAADLGE GNIPADIATL LKASLGL
//
