ID A0A3Q0GA58_ALLSI Unreviewed; 957 AA.
AC A0A3Q0GA58;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Chloride channel protein 1 isoform X4 {ECO:0000313|RefSeq:XP_025056534.1};
GN Name=CLCN1 {ECO:0000313|RefSeq:XP_025056534.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025056534.1};
RN [1] {ECO:0000313|RefSeq:XP_025056534.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_025056534.1; XM_025200749.1.
DR AlphaFoldDB; A0A3Q0GA58; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002243; Cl_channel-1.
DR PANTHER; PTHR45720:SF4; CHLORIDE CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01112; CLCHANNEL1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 85..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 107001 MW; F28103F5933ACE54 CRC64;
MESSEHKTEE PRSSSAIWDA GPQYDYVRFE KCNSYGIPME ARHETGGKGD DLNYLESTLS
YPQLYGQYTE QLSDFAQKEA VKLLSDKEDQ GNSQRPLKQD TQSEVKENRY SKCQAYKWMY
KEMHPNVLMQ YLAWVTYPLI LILFAAAFCH LVSPQAVGSG IPELKTIMRG VVLKEYLTLK
AFVAKVVGLT AGLGSGMPVG KEGPFVHIAS ICAAVLSKFM SIFCGVYEQP YYYTDVLTVG
CAVGVGCCFG TPLGGVLFSI EVTSTYFAVR NYWRGFFAAT FSAFIFRVLA VWNKDAVTIT
ALFRTNFRMD FPFDLQELPA FAVIGICCGF LGAFFVYLNR QVVLCVRRHK TLSQFLTKYR
LLYPGVITFL IATVTFPPGF GQFMAGELMP REAISSLFDN YTWVKYTGDP QVLGKSAVWI
HPNVSVFIII LLFFLMKFWM SVIATTMPIP CGGFMPVFVL GAAFGRLVGE IMASLFPDGI
LFDGLVYKIL PGGYAVIGAA ALTGAVSHTV STAVICFELT GQISHILPMM VAVILANMVA
QSLQPSLYDS IIQVKKLPYL PDLGWNHISK YNIFVEDIMV CDVKFISSNC TYRDLQTLLQ
TTTVKTLPLV DSPESMILLG SVERSELQAL LQRHISPERR LHLAKEMQQK LTEAPYDGSS
KSQWMAMPKW KRESFAFVDE DEDEEEKTEL SQQPTTAPSH SEKPNGPVTP YKRIPETPGL
QEPPEARRFW SFQQLIQQLL CNFSHSPEME STAQDSVEVV DTMKPEEIDA WEQEELNKEV
CFDSCRIDPS PFQLVERTSL HKTHTLFSLL SLSHAYVTSM GKLKGVLALE ELQKAIEGST
RSGVRLRPPL ASFRNTSRTS VSSEKANQVS QVWSRQNSCT VPMRGAVDSG AESPLPPSSL
SMQPLPFPEE GLPCGTDTEL EDMEMTRPAT ENISDILRDL SLHSTDLDED EEEDIPL
//
