ID A0A3Q0GB70_ALLSI Unreviewed; 1031 AA.
AC A0A3Q0GB70;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=mitogen-activated protein kinase kinase kinase {ECO:0000256|ARBA:ARBA00012406};
DE EC=2.7.11.25 {ECO:0000256|ARBA:ARBA00012406};
GN Name=MAP3K15 {ECO:0000313|RefSeq:XP_025056911.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025056911.1};
RN [1] {ECO:0000313|RefSeq:XP_025056911.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. MAP kinase kinase kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00006529}.
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DR RefSeq; XP_025056911.1; XM_025201126.1.
DR AlphaFoldDB; A0A3Q0GB70; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF363; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 15; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000313|RefSeq:XP_025056911.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|RefSeq:XP_025056911.1}.
FT DOMAIN 350..606
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 634..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 900..931
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 634..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 379
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1031 AA; 116971 MW; FD0211EB90B4D921 CRC64;
MLLCFWNEGA EKYTGGGVCC SGILFGVLFL RNNAGDREKA LQVMLQVFQT CDQPAPDMFC
LCGRIYKDMF LDSDCKDTSS RDSAIEWYRK GFELQSSLYS GINLAVLLLV AGQRFETSME
LRKIGVRLNS LLGRKGSLEK MNNYWDVGQF FSVSMLANDV GKAVQAAEKL FKLKPPVWYL
RSLVQNLLLI QRFKKLTIEH SPRQERLNFW LDIIFEATEE TTNGLRFPVL VIEPTKVYQP
AYVSINNEDD ERSLSLWHVS PTEVKQIHEW NFTASSIRGI SISKFDERCC FLYVHDNSDD
FQIYFSTESQ CSRFCALVKE MLTDAVGSSL ELEGEIDGDT LEYEYDYDEN GDKVILGKGT
YGVVYAGRDL SNQVRIAIKE IPEKDIRYSQ PLHEEIALHK YLKHRNIVQY LGSVSEDGYI
KIFMEQVPGG SLSVLLRSKW GPMKEPTIKF YTKQILEGLK YLHENQIVHR DIKGDNVLVN
TYSGVVKISD FGTSKRLAGI NPCTETFTGT LQYMAPEIID KGPRGYGAPA DIWSLGCTII
EMSTGKPPFH ELGEPQAAMF KVGMFKIHPE IPESLSAEAR AFILLCFEPD PHKRVAASDL
LKDPFLKQVT KGKKNRISFK PSDYNRSVSL PVQVPGEQAG SSSSEHGSVS PDSDVQHDMF
FEKTKRSVSE IQTKHNISNL LSVPDESSVS EDRSGSSSLE DKDSGLFLLR KDSERRAILY
KILKEEQNKV ASNLQECITQ SSEELQLSVP HIKQIIGILR DFIHSPEHRV MASTISKLKM
DLDFDSTSIN QIHLVLFGFQ DAVNKVLRNH LIRPHWMFAM DNIIRRAVQA AVTILIPELR
AHFEPASETE GVDKDGEEVE NNYQPAEQNG NEEPAVASGV NTISSVAYYD SKQRQLSLEL
GKIKQETNRL LENLVQKERE YQSLLRQTLE QRTLELHLLQ LKSKPAEFQE PLSDVSQNVD
PELINWLNEQ GVDSDAIKKF AEEDYTLNDV LNNIGKEDLR YLKLRGGLVC RIWNAILSHR
QMGDKLTDTE D
//
