ID A0A3Q0GCT5_ALLSI Unreviewed; 1433 AA.
AC A0A3Q0GCT5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Adhesion G protein-coupled receptor L2 isoform X9 {ECO:0000313|RefSeq:XP_025057424.1};
GN Name=ADGRL2 {ECO:0000313|RefSeq:XP_025057424.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025057424.1};
RN [1] {ECO:0000313|RefSeq:XP_025057424.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_025057424.1; XM_025201639.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd16006; 7tmB2_Latrophilin-2; 1.
DR CDD; cd22845; Gal_Rha_Lectin_LPHN2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF61; ADHESION G PROTEIN-COUPLED RECEPTOR L2; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 2.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_025057424.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 862..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1008..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1081..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..142
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 152..411
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 486..543
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 864..1105
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 434..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 153..335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1433 AA; 160937 MW; 3A7721012557C572 CRC64;
MRSPLQLTMY WRDWHSCGKE MFSSGFAKPH NQVHKPGFSR AALPFGLVRR ELSCEGYSID
LRCPGSDVIM IESANYGRTD DKICDADPFQ MENTECFLPD AYKIMTQRCN NRTQCIVVTG
SDVFPDPCPG TYKYLEVQYE CVPYKVEQKV FVCPGTLKAI VDSPYLYEAE QKAGAWCKDP
LQAADKIYFM PWTPYRTDTL IEYASLEDFQ NGRQQTTYKL PNRVDGTGFV VYDGAVFFNK
ERTRNIVKFD LRTRIKSGEA IINYANYHDT SPYRWGGKTD IDLAVDENGL WVIYATEQNN
GMIVISQLNP YTLRFEATWE TTYDKRAASN AFMICGVLYV VRSVYQDNES ETGKNTIDYI
YNTRLSRGEY ADVSFPNQYQ YIAAVDYNPR DNQLYVWNNN FILRYSLEFG PPDPAQVPTT
AVTITSSAEL YKTTVSTTST TSQKGPTSTT LSGGTKEGSK GPKPPPAVST TKIPPVTSFF
PLPERFCEPA EARGISWPQT QRGMMVERPC PKGTRGTASY LCMVSTGTWN PKGPDLSNCT
SHWVNQLAQK IRSGENAASL ANELAKHTKG PVFAGDVSSS VRLMEQLVDI LDAQLQELRP
SEKDSAGRSY NKLQKREKTC RAYLKAIVDT VDNLLRPEAL ESWKDMNSSE QAHAATMLLD
TLEEGAFVLA DNFVDPTRVS MPTENIVLEV AMLSTEGQVE DLKFPQGSKG GNSIQLSSST
IKQNSRNGLA KLVFIIYKSL GRFLSTENAT IKLGSDFIGR NSTIAVNSHV IAASINKESS
RVYLTHPVHF TLEHIDPDNY FNANCSFWNY SERTMMGYWS TQGCKLVDTN KTHTTCACSH
LTNFAILMAH REVVYKDGVH ELLLTVITWV GIVISLVCLA ICIFTFCFFR GLQSDRNTIH
KNLCINLFIA EFIFLIGIDK TEYKIACPIF AGLLHFFFLA AFAWMCLEGV QLYLMLVEVF
ESEYSRKKYY YVAGYLFPAT VVGVSAAIDY KSYGTEKACW LHIDNCFIWS FIGPVTFIIL
LNLIFLVITL CKMVKHSNTL KPDSSRLENI KSWVLGAFAL LCLLGLTWSF GLLFINEGTV
VMTYLFTVFN AFQGMFIFIF HCALQKKVRK EYGKCFRHSY CCGGLPTESP HSSVKASTTR
TSARYSSGTQ SRIRRMWNDT VRKQSESSFI SGDINSTSTL NQGHSLNNAR DTSAMDTLPL
NGNFNNSYSL RNGDYNDSVQ VVDCGLSLND TAFEKMIISE LVHNNLRGSS KNHNLERTLP
AKAVIGGSSS EDDAIVADAS SLMHSDNPGL ELHHKELEAP LIPQRTHSLL YQPQKKVKTE
GTDSYVSQLT AEAEDHLQSP NRDSLYTSMP NLRDSPYPES SPDVEEDLSP SRRSENEDIY
YKSMPNLGAG HQLQMYYQIS RGNSDGYIIP INKEGCIPEG DVREGQMQLV TSL
//
