ID A0A3Q0GDE4_ALLSI Unreviewed; 918 AA.
AC A0A3Q0GDE4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase alpha isoform X1 {ECO:0000313|RefSeq:XP_025056455.1};
GN Name=PTPRA {ECO:0000313|RefSeq:XP_025056455.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025056455.1};
RN [1] {ECO:0000313|RefSeq:XP_025056455.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00007765}.
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DR RefSeq; XP_025056455.1; XM_025200670.1.
DR AlphaFoldDB; A0A3Q0GDE4; -.
DR STRING; 38654.A0A3Q0GDE4; -.
DR InParanoid; A0A3Q0GDE4; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14621; R-PTPc-A-1; 1.
DR CDD; cd14623; R-PTPc-A-2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR016336; Tyr_Pase_rcpt_a/e-type.
DR InterPro; IPR027262; Tyr_Pase_rcpt_alpha.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF433; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PIRSF; PIRSF500808; PTPR_alpha; 1.
DR PIRSF; PIRSF002006; PTPR_alpha_epsilon; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|PIRSR:PIRSR002006-3};
KW Receptor {ECO:0000313|RefSeq:XP_025056455.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 357..617
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 537..608
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 649..907
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 823..898
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 128..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 558
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT ACT_SITE 848
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT BINDING 526
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 558..564
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 602
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT MOD_RES 914
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-3"
SQ SEQUENCE 918 AA; 103107 MW; 5C28A9C12DA7EAA3 CRC64;
MDLQAQPVPH TCCRTCDLLK RPCSCPSHSS IQLELLSFLG IQAANLIALF IHLFRHCSIL
QKISRHPTMP WHPGLVTAVV AKWCFYQCLF QLSAEQANMD LWFFVLLLGS GLTCLGADNI
TTVTHTTNLT SSTSSTEAST TQPGSGKSTS ATSTNASSSV TVSFGTVRTS GATAAMEPDN
FSSLGTENAT SKMASASPTS AFVTPSIAMS SVSSSRHPTV QDRGTTPTEG NETGPMIVMT
TEPLDSSDGT SKDPGDPNSD GRRDETPIIA VMVALSSLLV IVFIIIVLYM LRFKKYKQAG
SHSNSFRLSN GRTDDTEPQS MPLLARSPST NRKYPPLPVD KLEEEINRRM ADDNKLFREE
FNALPACPIQ ATCEAASKEE NKEKNRYVNI LPYDHSRVHL TPVEGVPDSD YINASFINGY
QEKNKFIAAQ GPKEETVNDF WRMIWEQNTA TIVMVTNLKE RKECKCAQYW PDQGCWTYGN
IRVSVEDVTV LVDYTVRKFC IQQVGDVTNK KPQRLVTQFH FTSWPDFGVP FTPIGMLKFL
KKVKTCNPQY AGAIVVHCSA GVGRTGTFIV IDAMLDMMHA ERKVDVYGFV SRIRAQRCQM
VQTDMQYVFI YQALLEHYLY GDTELEVTSL EIHLQKIYNK VPGTSSNGLE EEFKKLTSIK
IQNDKMRTGN LPANMKKNRV LQIIPYEFNR VIIPVKRGEE NTDYVNASFI DGYRQKDSYI
ASQGPLQHTI EDFWRMIWEW KSCSIVMLTE LEERGQEKCA QYWPSDGSVS YGDITVELKK
EEECESYTVR DLLVTNTREN KSRQIRQFHF HGWPEVGIPS DGKGMINIIA AVQKQQQQSG
NHPITVHCSA GAGRTGTFCA LSTVLERVKA EGILDVFQTV KSLRLQRPHM VQTLEQYEFC
YKVVQEYIDA FSDYANFK
//
