ID   A0A3Q0GGD8_ALLSI        Unreviewed;      1218 AA.
AC   A0A3Q0GGD8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Peroxidasin homolog isoform X4 {ECO:0000313|RefSeq:XP_025057455.1};
GN   Name=LOC102376607 {ECO:0000313|RefSeq:XP_025057455.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025057455.1};
RN   [1] {ECO:0000313|RefSeq:XP_025057455.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025057455.1; XM_025201670.1.
DR   AlphaFoldDB; A0A3Q0GGD8; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd09826; peroxidasin_like; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR034824; Peroxidasin_peroxidase.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   PANTHER; PTHR11475:SF54; PEROXIDASE; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   Pfam; PF07679; I-set; 4.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 4.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          46..134
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          142..228
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          233..304
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          321..412
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          1132..1168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         874
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   1218 AA;  136437 MW;  9F0142180E5DBB63 CRC64;
     MWLAELLKKY AEQGNIQTAA TCESPRELQG RSITTLTTQE LNCESPRITS EPHDADVMLG
     NTVYFTCRAE GNPKPEIIWL HNNNEIDMKD DGRLNLLQDG TLMIQNAKES DKGVYQCRAK
     NVAGEVKTQE VVLRYFGTPS KPSFVIQPQT TEVLVGESVT LECGVSGHPP PRISWTLGSG
     FPLPRDSRFT ITSSGGLYIQ NVTFADQGQY NCNASNMEGA IQATANIIVQ DSPRFLVVPT
     DQTATEGQSV DFPCSAEGRP PPVIAWTRAG GPLPSDRRHS ILSTGTLRVV RVALHDQGQY
     ECHAISAIGV RSLPVHLWVT PRVVPVFLHR PQDVEAETGQ DVVIICAARG DPRPTITWVK
     EGIQITDSGK FHMSQDGTLS IRDLGVADQG RYECIARNPF GFTSSTMQLT ITATDVGRSG
     DTFVASSIKE AISSVDHAIN STRTELFSKR PKTPNDLLAL FRYPRDPYTL ETARAGEIFE
     RTLQLIQDHV QQGLIVDMNV TGYRYNDLVS PHYLNMIANL SGCSAHRRTP NCSDICFHQK
     YRTHDGSCNN LQHPMWGASL TAFQRLLKPA YQNGFNLPRG VSLAEDSREL PLPLPRLVST
     AMIGTDTITP DEQFTHMLMQ WGQFLDHDMD QTVAAISMSR FSDGAPCSEV CTNDPPCFSI
     MIPENDPRVR NGRCMFFVRS SPVCGSGMTS LLMNSVYARE QINHLTSYID ASNVYGSTEQ
     ESRELRDLSN QKGLLKQGRV VPSSGKALLP FAVGPPTECM RDENESPVPC FLAGDHRANE
     QLGLTAMHTL WFREHNRIAT QLLALNPHWD GDTVYHEARK VVGAQMQHLT YAHWLPKVLG
     EAGMKMLGEY KGYSPNTNAG ILNAFATAAF RFGHTLINPF LYRLNESFQP IRQGHVRLHK
     AFFSPFRIMQ EGGIDPLLRG LFGIPGKMRV PSELLNMELT EKLFSMAHSV SLDLAAINIQ
     RGRDHGIPPY NDFRVFCNLT SAQEFEDLRN EIKNLEIREK LRSLYGTTKN IDLFPALMVE
     DLVPGTRVGP TLMCLLTTQF RRLRDGDRFW YENPGVFTPA QLTQIRQTSL ARIICDNSDH
     IRQLQGDVFQ VASYPQGMVS CEEIPAVDLR LWQDCCEDCR SRGQFQALSQ RFRGKRSPGF
     SYPEENPDKH KPAPPSSEEP SQSHSLRENL ESVVAELERT VSVLQRQVHA LEGQLRWHQR
     NTSAYGWRTK TGEKWRKR
//