ID A0A3Q0GH48_ALLSI Unreviewed; 175 AA.
AC A0A3Q0GH48;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=ADP-ribosylation factor-related protein 1 {ECO:0000256|ARBA:ARBA00039478};
GN Name=ARFRP1 {ECO:0000313|RefSeq:XP_025057493.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025057493.1};
RN [1] {ECO:0000313|RefSeq:XP_025057493.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Trans-Golgi-associated GTPase that regulates protein sorting.
CC Controls the targeting of ARL1 and its effector to the trans-Golgi.
CC Required for the lipidation of chylomicrons in the intestine and
CC required for VLDL lipidation in the liver.
CC {ECO:0000256|ARBA:ARBA00037377}.
CC -!- SUBUNIT: Interacts with SYS1. {ECO:0000256|ARBA:ARBA00038765}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000256|ARBA:ARBA00010290}.
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DR RefSeq; XP_025057493.1; XM_025201708.1.
DR AlphaFoldDB; A0A3Q0GH48; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd04160; Arfrp1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45909; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR45909:SF1; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
SQ SEQUENCE 175 AA; 19734 MW; EFBC9E8C85CE7A1A CRC64;
MYTLLSGLYK YIFQRDEYCV LILGLDNAGK TTFLEQTKIR FNRNYKGMSL SKITTTVGLN
IGTIDVGKVR LMFWDLGGQD ELQSLWDKYY AESHGVIYII DSTDEERLSE SKRAFEKMIT
SEVLEGVPIL VLANKQDVET CLSIPDIKTA FSDCINKIGK RDCLTQACSA LTGSE
//
