ID A0A3Q0GHM2_ALLSI Unreviewed; 276 AA.
AC A0A3Q0GHM2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Very-long-chain enoyl-CoA reductase-like isoform X2 {ECO:0000313|RefSeq:XP_025057668.1};
GN Name=LOC102383204 {ECO:0000313|RefSeq:XP_025057668.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025057668.1};
RN [1] {ECO:0000313|RefSeq:XP_025057668.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC {ECO:0000256|ARBA:ARBA00007742}.
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DR RefSeq; XP_025057668.1; XM_025201883.1.
DR AlphaFoldDB; A0A3Q0GHM2; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR039357; SRD5A/TECR.
DR InterPro; IPR049127; TECR-like_N.
DR PANTHER; PTHR10556; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR10556:SF59; S5A_REDUCTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02544; Steroid_dh; 1.
DR Pfam; PF21696; TECR_N; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 51..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..217
FT /note="Steroid 5-alpha reductase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50244"
SQ SEQUENCE 276 AA; 32199 MW; 2AAF5919C025751B CRC64;
MFHKSYPQWY PARQSIRLKP KGKALRDEEI LQNLPVGTTA TLYFKDLGPQ IGWTMVFLIE
YAGPLFIYFL FYFRMPFVYG LDERFTSRPH PVVNLACICH SFHYIKRLIE TVFVHRFSHG
TMPLRNIVKN CLYYWGFAAW LAYYINHPLY TPPSYGQKQI NIAVIMFLLC EAGNFSIHVA
LSDLRRDGSK IRKIPYPTKN PFTWLFFFVS CPNYTYEDRI FSMKGGIHAN SITRNVFNFL
GQTGGDLDQF HCHDSVCPSG IVYFALLYSD DNLGKR
//
