ID A0A3Q0GIN6_ALLSI Unreviewed; 918 AA.
AC A0A3Q0GIN6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5B {ECO:0000313|RefSeq:XP_025059327.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025059327.1};
RN [1] {ECO:0000313|RefSeq:XP_025059327.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR RefSeq; XP_006023183.1; XM_006023121.2.
DR RefSeq; XP_025059327.1; XM_025203542.1.
DR AlphaFoldDB; A0A3Q0GIN6; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF6; NETRIN RECEPTOR UNC5B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 348..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 135..216
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 517..660
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 850..916
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 918 AA; 102116 MW; 171893EA34B5980C CRC64;
MGIEYGDVLP DSFPSAPAET LPHFLLEPQD AYIVKNKPVE LICRANPATQ IYFKCNGEWV
NQNDHITKES LDEVTGMLVR EVQIEVSRQQ VEELFGLEDY WCQCVAWSSA GTTKSRRAYV
RIAYLRKNFD QEPLGKEVPL EHEVLLQCRP PEGVPPAEVE WLRNEDIIDT TQDTNFLITV
DHHLIIKQAR LSDTANYTCI AKNIVAKRRS TTATVIVYVN GGWSIWSEWS SCNNRCGHGW
QKRTRTCTNP APLNGGSICE GQAFQKIACT TMCPVDGAWT EWSKWSACST ECTHWRSREC
TAPSPRNGGK DCSGVLLDSK NCTDGLCMQN KRVLSEPKSH LLEATGDVAL YAGLVVAVFV
LIVILMAVGV VVYRRNCRDF DTDITDSSAA LTGGFHPVNF KTSRHDTPQL LHPSMQPDLT
ASAGIYRGPM YALQDSSDKI PMTNSPLLDP LPNLKIKVYN SSTVSSSPGL HEGADLLGAV
PIGTYSGETA RDNHFMNIRN KTMGSQHLLT QLREHGNSAS GTFGYLGGRL TIPDTGVSLL
VPHGAIPQGK FYEMYLIINK AENTLLPSEG TQTVLSPMVT CGPTGLLLCR PVILTIPHCV
DISSSDWIFQ LKTQSHQGNW EEVVTLDEET LNTPCYCQLE SKSCHILLDQ LGTYVFVGES
YSRSAIKRLQ LAIFAPAICT SLEYSIKVYC LEDTPDALKE VLELEKTLGG YLLEEPKPLL
FKDSYHNLRL SIHDIPHSLW RSKLLAKYQE IPFYHIWSGS QRALHCTFTL ERYSQASTEL
TCKICVRQVE GEGQIFQLHI TLGENASSFD AFHLHHGSAA TTQLGPYAFK IPLSIRQKIC
SSLDAPNSRG NDWRLLAQKL SMDRYLNYFA TKASPTGVIL DLWEAQHQDD GDLNTLASAL
EEMGKSEMLV VMATEGDC
//
