ID A0A3Q0GIS1_ALLSI Unreviewed; 857 AA.
AC A0A3Q0GIS1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL7 {ECO:0000313|RefSeq:XP_025059559.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025059559.1};
RN [1] {ECO:0000313|RefSeq:XP_025059559.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_025059559.1; XM_025203774.1.
DR AlphaFoldDB; A0A3Q0GIS1; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF85; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 7; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 23..118
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..204
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 791..818
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 96399 MW; D34FBB6057AE2001 CRC64;
MLGSESWEMV DEPRGRSGPG QELERQEGYM LKKRKWPLKG WHKRYFVLEE GILKYATTCQ
DVLKGKLHGS IDVRLSVMSV NKKAQRVDLD TEENIYHLKI KSQELFNSWV AKLCSHRLAE
KPEVPNYSAP KVRLPSSPSQ GCGSRAWVLP SGSTPALSTL TSPRDKVSTW LKNSECLERC
SAELSECQGK LQELNKMLQS LETLHRIPSA PLISNSQGSV GTERPKKGKR TTKIWCTQSF
AKDDTIGRVG RLHGSVPNLS RYLEPSQSQP AFSLPAEYNQ LQRNFWVLAQ KVHGSLSSVV
AVLTTERDRL REMQRALDLQ RSATRLGSAR NSTTPGSLDH QECLRRFHSL SLSSDATLDS
FTSLTPAEPD TLLVKGREQQ LSNRSIVSLS DSHTEFFDAC EVFLSASSSE NEASDDESCL
SEATNSISED TVDAGGAGRF HKAGLVAVDV PGTSEPGGGP LACQLLSLPM LASTGVPCRS
CLPAPNVHSG DVSLWNILRN NIGKDLSKVS MPVQLNEPLN TLQRLCEELE YSALLDAASC
SPDPCERLVY VAAFAVSAYA STYHRAGSKP FNPVLGETYE CVRPDKGFRF ISEQVCHHPP
ISACHAESDN FIFWQDMKWK NKFWGKSLEI IPVGTVNVQL PKFGDHFEWN KVTSCIHNIL
SGQRWIEHYG EVLIRNTKDS TYHCKITFCK ARYWGSNVNE VQGAVFSPSG KVIHRLFGKW
HEGLFRGTPP TGQCIWKPNP MPREYEKNYG FTQFALELNE LTPELKRFLP STDTRLRPDQ
RYLEEGNVQA AESQKRRIEQ LQRDRRRVME ENNIIHQARF FRRQTDSSGK ELWVSNGSYW
KLRLDPGYTN LDSAVLW
//
