ID A0A3Q0GIU3_ALLSI Unreviewed; 767 AA.
AC A0A3Q0GIU3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Transducin-like enhancer protein 1 isoform X2 {ECO:0000313|RefSeq:XP_025058285.1};
GN Name=TLE1 {ECO:0000313|RefSeq:XP_025058285.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025058285.1};
RN [1] {ECO:0000313|RefSeq:XP_025058285.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR RefSeq; XP_025058285.1; XM_025202500.1.
DR AlphaFoldDB; A0A3Q0GIU3; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF29; TRANSDUCIN-LIKE ENHANCER PROTEIN 1; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 15..130
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 567..608
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 609..650
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 125..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 23..50
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 137..151
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 82732 MW; AFF1A011BA947A48 CRC64;
MVVTSTPHQA AGQPFKFTIP ESLDRIKEEF QFLQAQYHSL KLECEKLASE KTEMQRHYVM
YYEMSYGLNI EMHKQTEIAK RLNTICAQVI PFLSQEHQQQ VAQAVERAKQ VTMAELNAII
GQQQLQAQHL SHGHGPPVPL TPHPSGLQPP GIPPLGSSAG LLALSSALGG QSHLAIKDDK
KHHDAEHHRD REPGTSNSLL VPDSLRSTDK RRNGPEYSND IKKRKVDDKD SSHYDSDADK
SDDNLVVDVS NEDPSSPRAS PSHSPRENGI DKNRLLKKDA SSSPASTASS GSSTSLKSKE
MSLHEKASTP VLKSSTPTPR SDVPTPGASA TPGLRPGLGK PPTMDPLVNQ AAAGLRTPLA
VPGPYPAPFG MVPHAGMNGE LTSPGAAYAS LHNMSPQMSA AAAAAAVVAY GRSPMVGFDP
PPHMRVPGIP PNLAGIPGGK PAYSFHVTAD GQMQPVPFPP DALIGPGIPR HARQINTLNH
GEVVCAVTIS NPTRHVYTGG KGCVKVWDIS QPGNKSPVSQ LDCLNRDNYI RSCKLLPDGC
TLIVGGEAST LSIWDLAAPT PRIKAELTSS APACYALAIS PDSKVCFSCC SDGNIAVWDL
HNQTLVRQFQ GHTDGASCID ISNDGTKLWT GGLDNTVRSW DLREGRQLQQ HDFTSQIFSL
GYCPTGEWLA VGMESSNVEV LHVNKPDKYQ LHLHESCVLS LKFAYCGKWF VSTGKDNLLN
AWRTPYGASI FQSKESSSVL SCDISVDDKY IVTGSGDKKA TVYEVIY
//
