ID A0A3Q0GJ65_ALLSI Unreviewed; 789 AA.
AC A0A3Q0GJ65;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=LOC102380162 {ECO:0000313|RefSeq:XP_025059464.1,
GN ECO:0000313|RefSeq:XP_025059466.1, ECO:0000313|RefSeq:XP_025059467.1,
GN ECO:0000313|RefSeq:XP_025059468.1, ECO:0000313|RefSeq:XP_025059469.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025059467.1};
RN [1] {ECO:0000313|RefSeq:XP_025059464.1, ECO:0000313|RefSeq:XP_025059466.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR RefSeq; XP_025059464.1; XM_025203679.1.
DR RefSeq; XP_025059466.1; XM_025203681.1.
DR RefSeq; XP_025059467.1; XM_025203682.1.
DR RefSeq; XP_025059468.1; XM_025203683.1.
DR RefSeq; XP_025059469.1; XM_025203684.1.
DR STRING; 38654.A0A3Q0GJ65; -.
DR OrthoDB; 1194at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF3; CHLORIDE CHANNEL PROTEIN CLC-KB; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361221};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 205..229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 422..440
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 525..544
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 591..608
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 647..707
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 789 AA; 87104 MW; 8AD2A2813F15B84B CRC64;
MATEGLDRRE HDVAKEEERI LILNEIWRPW PKTRRRVQGC LDCVKRQLFR VGEDWYFLFA
LGVIMAMISF VMDFTINTLL NAHRWLYQEL GDYLVLKYLS WTMYPIALVA FSTGYAQSIT
PHSGGSGIPE LKTILTGVML EDYLAIKNFG AKVVGMTCTL AAGSTIFLGK VGPFVHISSI
MAAYLGKIRT SVIGEYENKS KQNEMLVAGA AVGVSTVFGA PISGVLFSIE VVSSHFAVRD
YWRGFFSATC GAFMFRLLAV FNNDQETIMA PFKTNFKIDF PFDLPEIFFF MILGVICGII
SCAYLFCQRW LLGYIRRNKL TAWLMATEIS TASGCLLVLS KVPCARQAAE THPHPGVLFL
LLPAGLPMLP APWRRWAPLP AAAGRGNCPF PDTFAGCQPL LRGEGSMNII GINLQGPLSK
PVYSALVALL LSSITFPPSL GQFMASRLTM KEYLSCFFDN QTWGVLSQNA SLARPLQVDP
ENLWMEWWDP NITIYGSLVI FIVMKFWMLI LATTLPMPAG YFMPIFVYGA GIGRLIGEVV
AFLFPHGIKL DGAANPIIPG GYALAGAAAF SGSVTHTIST ALLVFEVTGQ IAHILPVILA
VLIANAIAQK FQPSFYDGTI IVKKLPYLPR IRSRHIDSYR VTTDQFMNTD FAVLPKGATF
EEILQVVTST DDLEYPIVES AESLLLVGTV PRSELVKFLQ THEDAKLSSQ EAGEKDKALC
SGTLGENCTI NPITFQLSPC TSLHQTHHLF ELLNLQRVFV TSLGRVIGAV SRSEVKKAIE
DLANPKTAK
//
