ID A0A3Q0GJ71_ALLSI Unreviewed; 1244 AA.
AC A0A3Q0GJ71;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Cation-transporting ATPase {ECO:0000256|RuleBase:RU362082};
DE EC=7.2.2.- {ECO:0000256|RuleBase:RU362082};
GN Name=ATP13A2 {ECO:0000313|RefSeq:XP_025059472.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025059472.1};
RN [1] {ECO:0000313|RefSeq:XP_025059472.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|RuleBase:RU362082};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362082}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362082}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000256|ARBA:ARBA00006000,
CC ECO:0000256|RuleBase:RU362082}.
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DR RefSeq; XP_025059472.1; XM_025203687.1.
DR AlphaFoldDB; A0A3Q0GJ71; -.
DR STRING; 38654.A0A3Q0GJ71; -.
DR InParanoid; A0A3Q0GJ71; -.
DR OrthoDB; 6047at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015662; F:P-type ion transporter activity; IEA:InterPro.
DR CDD; cd07542; P-type_ATPase_cation; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR047819; P5A-ATPase_N.
DR InterPro; IPR047821; P5B-type_ATPase.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 3.
DR NCBIfam; TIGR01657; P-ATPase-V; 1.
DR PANTHER; PTHR45630; CATION-TRANSPORTING ATPASE-RELATED; 1.
DR PANTHER; PTHR45630:SF2; POLYAMINE-TRANSPORTING ATPASE 13A2; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF12409; P5-ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362082};
KW Magnesium {ECO:0000256|RuleBase:RU362082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362082};
KW Metal-binding {ECO:0000256|RuleBase:RU362082};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362082};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362082};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362082}.
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 281..297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 303..321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 477..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 510..533
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 988..1007
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1013..1030
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1051..1074
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1100..1121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1133..1152
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1172..1196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT DOMAIN 79..220
FT /note="P5B-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12409"
FT DOMAIN 245..296
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00690"
SQ SEQUENCE 1244 AA; 137357 MW; 84B1DFB999B4B760 CRC64;
MLLLGKSQLE LCLIGPRAGS LSFLQAIREA AASSCPAPRP QGCSVGCISL PEHRPSDSSR
LMRNQQPGYG ALLQVPDKSC MEVSGYQSRT WKVVLCHLFS VLTAGLLLIV FHWKPSLEVR
AKCRPCPLSQ ADWVIIQDGF GQCFTTRVQT EEIGDGREAG LLRYGQSLEQ HPGTRPDDGR
ASVAVGVTDE DDGRDTIQLH KKEEKNILRY YLFEGSRYVW LERQQAYCKV SILDEGWTCA
DIRLSQAGLT QQDHNTKRKI YGPNLIDVPV KSYLRLLVDE VLNPFYIFQI FSIVLWICDT
YYYYAACIFV ISAISIGLSL YETRKQSKTL QNMVKMAISV RVRRPSGGEA MVSSEDLVPG
DCISLPCDGL LVPCDAALLT GECMVNESML TGESVPVMKT PLPDGPQAIN LIYSPEEHKR
HTLFCGTQVL QAKSYVGQDV LAVVTRTGFC TAKGDLISSI LYPKPLSFKF YKDAMKFVLF
LAVLALIGTI YSILILIRNK VALGQIIIRA LDLITVIVPP ALPAAMTVGT IYAQNRLKKH
GIFCVSPPRI NLCGKIHLVC FDKTGTLTED GLDVWGVVPL ENSCFLPLIQ EPRCLPDGPL
LYSLSTCHTV SLLREQPIGD PVDLKMMEST GWILEKAEGE EADLHAIQQF GTKVLAVMKP
PPVEEQPHGT KHQVPVGILR RFPFSSSLQR MSVVVKLPGD APAEAYAKGA PEMVASLCNK
ETVPGDFSQM LRHYTTDGFR VLALAYKPLA PVKTFEDAQQ LTRDAVESGL TLLGFLVMKN
VLKAETAPVI HLLRKASLRP VMVTGDNMLT AVNVAKSCRM VEPKERVVFV NGSPPDHDRP
AALKFSLAEQ APGQELAEGP YQQEGCLLRQ LPSHLALNGK SFAVVCEHFP DLLPKILVQA
TIFARMSPDQ KTRLVRCLQD LNYCVGMCGD GANDCGALKA ADVGISLSEA EASVASPFTS
RIPNIECVPL VIREGRCSLV TSFGVFKYMA LYSLVQFVSV LLLYTINTNL SDLQFLFFDL
IITTTVAVLM GKTGPAQELG TQRPQGALIS VLVLGSLLLQ TALLIIVQVA SYFITVSQTW
YVPLNSTVTA PQNLPNYENT VVFCISGFQY LTLAVAMSKG YPFRKPLYTN VPFLLALVIL
FGLMIGVTVY PLGFVKSLLM LKDTSDMNFK LLLVGMATLN FFVAFTLETA LDHGMLDWVR
KLRRKKTSKK LFKRVEEELR RQQPPWPPLD QPLLATPRMS IAVR
//
