ID A0A3Q0GLH6_ALLSI Unreviewed; 1062 AA.
AC A0A3Q0GLH6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN Name=GUCY2C {ECO:0000313|RefSeq:XP_025060599.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025060599.1};
RN [1] {ECO:0000313|RefSeq:XP_025060599.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR RefSeq; XP_025060599.1; XM_025204814.1.
DR AlphaFoldDB; A0A3Q0GLH6; -.
DR STRING; 38654.A0A3Q0GLH6; -.
DR KEGG; asn:102374400; -.
DR InParanoid; A0A3Q0GLH6; -.
DR OrthoDB; 3683909at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF347; GUANYLYL CYCLASE C; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000313|RefSeq:XP_025060599.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1062
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018210558"
FT TRANSMEM 421..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 479..739
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 814..944
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1062 AA; 122024 MW; 98D2A84BEF71BCDC CRC64;
MLGPACWLLL LCLQLLWPPG AGKCDKDNYV INVMLLNDAQ YPWIFENVQP AVEWGLRVIE
EELQKAGKPV TLNATYNGFN TSLYVSRGCP TSTCEGVEIV KQLYNTGTLG CIVLGPTCTY
ATYQMVSVDT ILSLPLISAG SFGLSCDYKA NLTRILTPAR KLTYFLLHFW HEFELPFKTR
AWETAYLYKK NLNTEDCFWY MNALESRITY FSEKLKFQEI LRSPDQLRKM MKNPNRKSNV
IIMCGSQTDV DAAIGEEELD EDIVFILLDI HNNTYFQNTT SPKYMRHVLV LTLAPSNFSL
NITDTMQKND FVIGYLNGVL LFGHVLKKFI LANQPVLPVN FIKEFRNVTF EGARGPVIVD
EFGDLDVNLT LMYTSMDTSE FKILLQFDTH RNKTEVKTDN PFFTWRNHKL PSDIPGTGPN
ILTIAVFTLT GAVILILVIA LLVLRKYRRD NELRQKKWFH IPPDKIMPLE TNETSPVSLK
IDEDRRRDTA QRLRQGKYDK KVVILKDFKY NDGNFTEKQK IELNKLLQID YYNLTKFYGT
VKIDAMIFGV IEYCERGSLR DVLNDKISYP DGTFMDWEFK ISVMYDIAKG MSYLHSSKTE
VHGRLKSTNC VVDSRMVVKI TDFGCNSILP PKKDLWTAPE HLRKADVSQK GDVYSYGIIA
QEIILRRETF YTGYCQDFKE KLYRVESGKG RQPFRPDLFL ETAGERELEV YTLVKSCWDE
DSEKRPDFKK IESSLAKIFS NYHSQTNESY MDTLIRRLQL YSRNLEHLVE ERTELYKAER
DRADKLNFML LPGPVVKSLK ETGGVEPELF EEVTIYFSDI VGFTTLCKYS TPMEVVDMLN
DIYKNFDHIL DHHDVYKVET IGDAYMVVSG LPKRNGNRHA VDISMMALDI LSFMGTFELR
HLPGLPVWIR IGIHSGPCAA GVVGIKMPRY CLFGDTVNTA SRMESTGLPL RIHVSGSTIA
ILKRTDCQFQ YEERGETYLK GRGTEITYWL TGVEDGKYNL PTPPSVENQQ RLQADLAKMI
TECLQRQEEG FQAHEPARVT SYRKGTLEYL QLATTENSST YL
//
