ID A0A3Q0GN92_ALLSI Unreviewed; 821 AA.
AC A0A3Q0GN92;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Dual serine/threonine and tyrosine protein kinase isoform X2 {ECO:0000313|RefSeq:XP_025061236.1};
GN Name=DSTYK {ECO:0000313|RefSeq:XP_025061236.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025061236.1};
RN [1] {ECO:0000313|RefSeq:XP_025061236.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}. Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell junction
CC {ECO:0000256|ARBA:ARBA00004282}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}.
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DR RefSeq; XP_025061236.1; XM_025205451.1.
DR AlphaFoldDB; A0A3Q0GN92; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR46392; DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE; 1.
DR PANTHER; PTHR46392:SF1; DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_025061236.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 531..798
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT COILED 340..371
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 611
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 821 AA; 93630 MW; B0EC1D35D671C2DC CRC64;
MWATAARRTV GKAPFLLFRD GQLNFISFPR HEEEYLQLTV NWHPCLLILG QNCNAKCQLL
NMLLGEKLLP TTKISSEENC KRRRIRFTHG TQTRISLALP GQYELVHMLA AHQGQWDTIP
EEDLEIHGDS EDPAHRIAEL EVTLPYSLLK EVDIVVAPCR GFQSAEVTLG EYVNHVLPVI
TFAISEAELS ASDENELREI KEKYALPVFF FKVPELGAEL ISPKKVENEK SSLYCQLMDL
EYLSINHCSC GAPTSEAKAQ SMLVEQSEKL RLLSVFSRQV LQKHLVDAAT LLNLVHSRCL
DIFINQAFDM QRDLQITPKR LEYTRKKENE LFESLMSIAN RKQEEMKDMI IETLNNMKEE
LLEDAANMEF KDIIIPENGE PVSSKDIKCC IKQIQELIIS RLNQEVANKL ISSVDYLRES
FVGTLERCLR SLEKSQDVSV HITSNYLKQI LNAAYHVEVT FHSGSTVTRM LWEQIKQIIQ
RITWVSPPAI TTEWKRKIAQ DAIESLSASK LAKSICSQFR TRLNSSHEAF AASLRQLEAG
HSGRLEKTED LWLKVRKDHA PRLARLSLES RSLQDVLLHG KPKLGRELGR GQYGVVYLCD
TWGGHFPCAL KSVVPPDEKH WNDLALEFHY MRSLPKHERL VDLHGSVIDY GYGGGSSIAV
LLIMERLHRD LYTGLKLDKK NRAKITDLGF CKPEAMMSGS IVGTPIHMAP ELFTGKYDNS
VDVYAFGILF WYLCSGHVKL PEAFERCASK DHLWNNVKRG VRPERLPVFD EECWQLMEAC
WDGDPSQRPL LGIVQPMLQR IMDRLCKSNS EQSNKGLDDS T
//
