ID A0A3Q0GPJ1_ALLSI Unreviewed; 1324 AA.
AC A0A3Q0GPJ1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neurofascin isoform X5 {ECO:0000313|RefSeq:XP_025061317.1};
GN Name=NFASC {ECO:0000313|RefSeq:XP_025061317.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025061317.1};
RN [1] {ECO:0000313|RefSeq:XP_025061317.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR RefSeq; XP_025061317.1; XM_025205532.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1194..1215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..132
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 138..225
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 239..327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 332..419
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 425..512
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 516..603
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 625..720
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 725..818
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 823..925
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 929..1032
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1224..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1324 AA; 147696 MW; F1A28BE8A99E9EB0 CRC64;
MVRQRYLLTC TGVVLAVCLH HIIRAIEVPL DLPQPPTIIK QSVKDYIVDP RDNIFIECEA
KGNPIPTFSW TRNGKFFNVA KDPKVSMQYR SGTLMIDIHS RGRPEDYEGE YQCFARNDYG
TALSNKMHLQ VSKSPLWPKE KVDVIEVDEG APLSLQCNPP PGLPPPVIFW MSSSMEPIHQ
DKRVSQGQNG DLYFSNVMLQ DAQTDYSCNA RFHFTHTIQQ KNPYSLKVKT TRGVTETTPS
FMYPYGTSSS QMVLRGVDLL LECIASGVPA PDIMWYKKGG LLPAGKSKFE NFNKALRISN
VSEEDSGEYF CLASNKVGLI RHTISVRVKA APYWLDEPQN LILAPGEDGR LVCRANGNPK
PTIQWLMNGE PIESSSPNLS REVSGDTIVF RDTQIGSSAV YQCNASNEHG YLLANAFVSV
LDVPPRILAP RNQLIKVILY NRTRLGCPFF GSPIPTLRWF KNGQGSTLDG GNYQVHENGT
LEMNMARKED QGIYTCVATN ILGKAENQVR LEVKDPTRIV RGPEDQVVKK GSMVRLDCRI
KHDSTLKLTV NWLKDNTGLH IGKGMKKEDD GLTIHGVAEK DQGDYTCIAS TELDKDSAKA
HLTVLAIPSV PTNRMTALPK GRPNPPRDLE LTDLAERSVR LTWIPGDDNN SPITDYVVQF
EEDRFQAGTW HNHSSYPGSV NSAVLRLSPY VNYQFRVIAV NDVGSSLPSL PSERYQTNGA
RPEINPTGIQ GVGTQKNNME ITWTPLNATQ TYGPNLRYIV KWRRRDTRES WSNVTVRNTR
YVVWNTPIYV PYDIKVQAEN DFGRAPEPDV VIGYSGEDYP KAAPTDIRLR VLNSTAVGLQ
WTRVYPDTVQ GQLKEYRAYY WRESSLLKNL WVSRKRQHTS FLGDRPRGTV SQLFPYSNYK
LEMAVVNGRG DGPRSEIKEF TTPEGVPSIP RYLRIGQPNM ETITLEWDHP EHPNGILTGY
NLRYQAFNGS KVGKTVGENF SPNQTRFTLQ RTDPISRYRF FLRARTQVGD GAVLMKESPA
LLNEAATWLP PTTVDLTSPT TTTTLATTTT TTTAATTTTT AATTTATTTV ASTTTTTESA
QPATTKQEFA ANGSSIWNVT ASANSNWANI TWSHNFSAGT HFVVEYMDRN NTVRSVAVKA
QTPSSVQLAD LIPGMEYKLW VFPKLSGPKE NSYITFTTSS AYTKNHADIA TQGWFIGLMC
AIALLVLILL IVCFIKRSRG GKYPVRDNKE EHLNPEDKNV EDGSFDYSDE DNKPLPNSQT
SLDGTIKQQE SDDSLVDYGE GGEGQFNEDG SFIGQYTVKK DKEETEGNES SEATSPVNAI
YSLA
//
